Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 831632..832289 Replicon chromosome
Accession NZ_OV754010
Organism Klebsiella pneumoniae isolate BB1541

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag O0V11_RS04160 Protein ID WP_002916310.1
Coordinates 831879..832289 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag O0V11_RS04155 Protein ID WP_002916312.1
Coordinates 831632..831898 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O0V11_RS04130 (VKR_00820) 826788..828221 - 1434 WP_064145187.1 6-phospho-beta-glucosidase -
O0V11_RS04135 (VKR_00821) 828340..829068 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
O0V11_RS04140 (VKR_00822) 829118..829429 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
O0V11_RS04145 (VKR_00823) 829593..830252 + 660 WP_002916317.1 hemolysin III family protein -
O0V11_RS04150 (VKR_00824) 830403..831386 - 984 WP_064145188.1 tRNA-modifying protein YgfZ -
O0V11_RS04155 (VKR_00825) 831632..831898 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
O0V11_RS04160 (VKR_00826) 831879..832289 + 411 WP_002916310.1 protein YgfX Toxin
O0V11_RS04165 (VKR_00827) 832296..832817 - 522 WP_004144730.1 flavodoxin FldB -
O0V11_RS04170 (VKR_00828) 832918..833814 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
O0V11_RS04175 (VKR_00829) 833837..834550 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
O0V11_RS04180 (VKR_00830) 834556..836289 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T295055 WP_002916310.1 NZ_OV754010:831879-832289 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT295055 WP_002916312.1 NZ_OV754010:831632-831898 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References