Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 47940..48676 Replicon plasmid BB1542_1
Accession NZ_OV753988
Organism Klebsiella pneumoniae isolate BB1542

Toxin (Protein)


Gene name tacT Uniprot ID L7SZ15
Locus tag O0552_RS25985 Protein ID WP_003026803.1
Coordinates 48194..48676 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag O0552_RS25980 Protein ID WP_003026799.1
Coordinates 47940..48206 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O0552_RS25960 43676..44131 - 456 Protein_39 transposase domain-containing protein -
O0552_RS25965 44242..45473 - 1232 Protein_40 IS3 family transposase -
O0552_RS25970 47000..47305 + 306 WP_074443076.1 CPBP family intramembrane metalloprotease -
O0552_RS25975 (VKR_05115) 47455..47716 - 262 Protein_42 transposase -
O0552_RS25980 (VKR_05116) 47940..48206 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
O0552_RS25985 (VKR_05117) 48194..48676 + 483 WP_003026803.1 GNAT family N-acetyltransferase Toxin
O0552_RS25990 48887..50233 + 1347 WP_077251107.1 ISNCY family transposase -
O0552_RS25995 (VKR_05119) 50393..51097 + 705 WP_040167821.1 toll/interleukin-1 receptor domain-containing protein -
O0552_RS26000 (VKR_05120) 51229..51810 + 582 Protein_47 heat resistance protein YfdX2 -
O0552_RS26005 (VKR_05121) 51900..52541 + 642 WP_023329026.1 heat resistance membrane protein HdeD-GI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid qnrB19 / floR / tet(A) - 1..205644 205644
- inside IScluster/Tn - - 44242..50233 5991


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17353.97 Da        Isoelectric Point: 9.5822

>T295052 WP_003026803.1 NZ_OV753988:48194-48676 [Klebsiella pneumoniae]
VGRITTPEPLSSSHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT295052 WP_003026799.1 NZ_OV753988:47940-48206 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2GNW6

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References