Detailed information of TA system TA029505

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-PHD
• Location: 89679..90364
• Replicon: plasmid 2
• Accession: NC_021279
• Organism: Mycobacterium abscessus subsp. bolletii 50594

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: R4V0C7
• Locus tag: MASS_RS26450
• Protein ID: WP_016341484.1
• Coordinates: 89679..90089 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: MASS_RS26455
• Protein ID: WP_016341485.1
• Coordinates: 90086..90364 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MASS_RS26430	84916..85260	-	345	WP_041928351.1	hypothetical protein	-
MASS_RS26675	85352..87667	-	2316	WP_131807328.1	hypothetical protein	-
MASS_RS26680	87866..88522	-	657	WP_051223733.1	hypothetical protein	-
MASS_RS26445	88591..89553	-	963	WP_041928353.1	hypothetical protein	-
MASS_RS26450	89679..90089	-	411	WP_016341484.1	type II toxin-antitoxin system VapC family toxin	Toxin
MASS_RS26455	90086..90364	-	279	WP_016341485.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MASS_RS26460	90554..91534	-	981	WP_041928355.1	hypothetical protein	-
MASS_RS26465	91784..92170	-	387	WP_016341487.1	hypothetical protein	-
MASS_RS26470	92167..93816	-	1650	WP_016341488.1	PPE protein	-
MASS_RS26475	93813..94121	-	309	WP_016341489.1	hypothetical protein	-
MASS_RS26480	94118..94429	-	312	WP_041928357.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..97240	97240

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-118)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-43)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 14741.89 Da
• Isoelectric Point: 4.4809

>T29505 WP_016341484.1 NC_021279:c90089-89679 [Mycobacteroides abscessus subsp. bolletii 50594]
VIYMDTSALTKLLIEEDETPELQAWLREQRGQDQYAATSAIGRVELIRVVARQGEPGLRERALYLLDGLDILPITAAVIT
LAERIGPATLRSLDAIHLASASQIAGELSAVVAYDIRLLEGCRAVGFRTQSPGAID

Nucleotide

• Length: 411 bp

>T29505 NC_021279:c90089-89679 [Mycobacteroides abscessus subsp. bolletii 50594]
GTGATCTATATGGACACCTCAGCCCTGACGAAGCTGCTGATCGAGGAGGACGAGACACCGGAGCTGCAAGCCTGGCTCAG
AGAGCAACGAGGACAGGACCAGTACGCGGCGACCAGCGCCATCGGCCGAGTTGAGCTGATAAGAGTCGTTGCACGACAAG
GAGAGCCAGGCTTGCGTGAGCGGGCACTGTACTTGCTCGACGGGCTGGACATACTGCCGATCACCGCCGCCGTGATCACA
CTGGCCGAAAGGATCGGCCCGGCCACTCTCAGATCGTTGGATGCGATTCACCTTGCCTCGGCAAGCCAGATCGCCGGCGA
GCTATCAGCAGTCGTCGCCTACGACATCCGACTACTTGAGGGATGCCGGGCAGTCGGGTTCCGCACCCAATCCCCTGGCG
CAATCGACTAG

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 9941.38 Da
• Isoelectric Point: 8.7933

>AT29505 WP_016341485.1 NC_021279:c90364-90086 [Mycobacteroides abscessus subsp. bolletii 50594]
MEMIGVRELRQNASPYLARVEAGETLGVTNNGRLIARLVPVGGAERSHEALISAGVLVPASRPNNLLDITATPRGSRKPS
LTTILHEMRDEQ

Nucleotide

• Length: 279 bp

>AT29505 NC_021279:c90364-90086 [Mycobacteroides abscessus subsp. bolletii 50594]
ATGGAGATGATAGGCGTTCGGGAGCTGCGGCAGAACGCGTCACCGTATTTGGCCAGGGTGGAAGCGGGCGAGACCCTGGG
TGTAACGAACAACGGCAGGCTGATCGCGCGCCTTGTGCCTGTAGGGGGCGCAGAACGCTCCCATGAGGCATTGATCAGTG
CGGGCGTCCTGGTGCCCGCTAGTCGGCCAAACAACCTGCTCGATATCACAGCAACTCCCCGGGGGAGCCGGAAGCCGAGC
CTGACCACGATTCTTCACGAGATGCGCGACGAGCAGTGA

Structures

Toxin

• AlphaFold DB: R4V0C7