Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4740828..4741344 Replicon chromosome
Accession NZ_OV753987
Organism Klebsiella pneumoniae isolate BB1542

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag O0552_RS23115 Protein ID WP_004178374.1
Coordinates 4740828..4741112 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag O0552_RS23120 Protein ID WP_002886901.1
Coordinates 4741102..4741344 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O0552_RS23090 (VKR_04533) 4736245..4736508 - 264 WP_025987940.1 PTS sugar transporter subunit IIB -
O0552_RS23095 4736638..4736811 + 174 WP_019725541.1 hypothetical protein -
O0552_RS23100 (VKR_04534) 4736814..4737557 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
O0552_RS23105 (VKR_04535) 4737914..4740052 + 2139 WP_019725540.1 anaerobic ribonucleoside-triphosphate reductase -
O0552_RS23110 (VKR_04536) 4740360..4740824 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
O0552_RS23115 (VKR_04537) 4740828..4741112 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
O0552_RS23120 (VKR_04538) 4741102..4741344 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
O0552_RS23125 (VKR_04539) 4741422..4743332 - 1911 WP_019725539.1 PRD domain-containing protein -
O0552_RS23130 (VKR_04540) 4743355..4744509 - 1155 WP_004178372.1 lactonase family protein -
O0552_RS23135 (VKR_04541) 4744576..4745316 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T295049 WP_004178374.1 NZ_OV753987:c4741112-4740828 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT295049 WP_002886901.1 NZ_OV753987:c4741344-4741102 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References