Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4616823..4617633 Replicon chromosome
Accession NZ_OV753987
Organism Klebsiella pneumoniae isolate BB1542

Toxin (Protein)


Gene name KacT Uniprot ID A0A0H3GMP0
Locus tag O0552_RS22575 Protein ID WP_002887280.1
Coordinates 4616823..4617356 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag O0552_RS22580 Protein ID WP_002887278.1
Coordinates 4617367..4617633 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O0552_RS22570 (VKR_04429) 4615654..4616775 + 1122 WP_009309849.1 cupin domain-containing protein -
O0552_RS22575 (VKR_04430) 4616823..4617356 - 534 WP_002887280.1 type II toxin-antitoxin system toxin KacT Toxin
O0552_RS22580 (VKR_04431) 4617367..4617633 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
O0552_RS22585 (VKR_04432) 4617736..4619169 - 1434 WP_019724905.1 Cu(+)/Ag(+) sensor histidine kinase -
O0552_RS22590 (VKR_04433) 4619159..4619842 - 684 WP_004214143.1 copper response regulator transcription factor CusR -
O0552_RS22595 (VKR_04434) 4620014..4621396 + 1383 WP_019724904.1 efflux transporter outer membrane subunit -
O0552_RS22600 (VKR_04435) 4621414..4621758 + 345 WP_025987660.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19838.70 Da        Isoelectric Point: 5.2614

>T295047 WP_002887280.1 NZ_OV753987:c4617356-4616823 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHVMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT295047 WP_002887278.1 NZ_OV753987:c4617633-4617367 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5ZGN
PDB 5XUN

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References