Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2656283..2657871 Replicon chromosome
Accession NZ_OV753987
Organism Klebsiella pneumoniae isolate BB1542

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag O0552_RS13060 Protein ID WP_002904792.1
Coordinates 2656283..2657605 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag O0552_RS13065 Protein ID WP_002904790.1
Coordinates 2657605..2657871 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O0552_RS13045 (VKR_02563) 2651339..2653840 + 2502 WP_064145444.1 fimbria/pilus outer membrane usher protein -
O0552_RS13050 (VKR_02564) 2653828..2654832 + 1005 WP_064145446.1 fimbrial protein -
O0552_RS13055 (VKR_02565) 2654974..2656266 + 1293 WP_064145447.1 glycoside hydrolase family 10 protein -
O0552_RS13060 (VKR_02566) 2656283..2657605 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
O0552_RS13065 (VKR_02567) 2657605..2657871 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
O0552_RS13070 (VKR_02568) 2658259..2658585 - 327 WP_002904788.1 hydroxyisourate hydrolase -
O0552_RS13075 (VKR_02569) 2658582..2659082 - 501 WP_064145448.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
O0552_RS13080 (VKR_02570) 2659060..2660439 - 1380 WP_064145449.1 nucleobase:cation symporter-2 family protein -
O0552_RS13085 (VKR_02571) 2660785..2661939 + 1155 WP_023282572.1 FAD-dependent urate hydroxylase HpxO -
O0552_RS13090 (VKR_02572) 2661920..2662843 - 924 WP_064145450.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T295045 WP_002904792.1 NZ_OV753987:c2657605-2656283 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT295045 WP_002904790.1 NZ_OV753987:c2657871-2657605 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References