Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 88870..89606 Replicon plasmid BB1501_1
Accession NZ_OV753635
Organism Klebsiella quasipneumoniae isolate BB1501

Toxin (Protein)


Gene name tacT Uniprot ID A0A8T5ZF70
Locus tag OZE11_RS26585 Protein ID WP_004187044.1
Coordinates 89124..89606 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag OZE11_RS26580 Protein ID WP_003026799.1
Coordinates 88870..89136 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OZE11_RS26555 (VKR_05279) 83879..84082 + 204 WP_004150739.1 HHA domain-containing protein -
OZE11_RS26560 (VKR_05280) 84190..85158 + 969 WP_013815099.1 IS5-like element IS903B family transposase -
OZE11_RS26565 (VKR_05281) 85233..85736 + 504 WP_256656753.1 cytosine permease -
OZE11_RS26570 (VKR_05282) 85748..86956 + 1209 WP_057072740.1 imidazolonepropionase -
OZE11_RS26575 (VKR_05283) 86949..87758 + 810 WP_023329017.1 N-formylglutamate deformylase -
OZE11_RS26580 (VKR_05284) 88870..89136 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
OZE11_RS26585 89124..89606 + 483 WP_004187044.1 GNAT family N-acetyltransferase Toxin
OZE11_RS26590 (VKR_05285) 89817..91163 + 1347 WP_151114741.1 ISNCY family transposase -
OZE11_RS26595 (VKR_05286) 91320..92027 + 708 WP_087796141.1 toll/interleukin-1 receptor domain-containing protein -
OZE11_RS26600 (VKR_05287) 92289..93635 + 1347 WP_267668018.1 ISNCY family transposase -
OZE11_RS26605 (VKR_05288) 93684..94079 + 396 WP_021312679.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..207699 207699
- inside IScluster/Tn - - 84190..104230 20040


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(46-148)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17280.93 Da        Isoelectric Point: 8.7197

>T295037 WP_004187044.1 NZ_OV753635:89124-89606 [Klebsiella quasipneumoniae]
VGCITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTYERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT295037 WP_003026799.1 NZ_OV753635:88870-89136 [Klebsiella quasipneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References