Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 12815..13340 Replicon plasmid BB1501_1
Accession NZ_OV753635
Organism Klebsiella quasipneumoniae isolate BB1501

Toxin (Protein)


Gene name ccdB Uniprot ID A0A7H9GHC5
Locus tag OZE11_RS26200 Protein ID WP_009309918.1
Coordinates 12815..13120 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A1D8K3R4
Locus tag OZE11_RS26205 Protein ID WP_006788213.1
Coordinates 13122..13340 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OZE11_RS26165 (VKR_05204) 8104..9081 - 978 Protein_9 IS5 family transposase -
OZE11_RS26170 (VKR_05205) 9477..9590 + 114 WP_014343462.1 hypothetical protein -
OZE11_RS26175 (VKR_05206) 9719..9976 + 258 WP_009310077.1 hypothetical protein -
OZE11_RS26180 (VKR_05207) 10034..10813 - 780 WP_023287113.1 site-specific integrase -
OZE11_RS26185 (VKR_05208) 11011..12027 - 1017 WP_009309921.1 hypothetical protein -
OZE11_RS26190 (VKR_05209) 12061..12396 - 336 WP_009309920.1 hypothetical protein -
OZE11_RS26195 12446..12586 - 141 WP_162898808.1 hypothetical protein -
OZE11_RS26200 (VKR_05211) 12815..13120 - 306 WP_009309918.1 type II toxin-antitoxin system toxin CcdB Toxin
OZE11_RS26205 (VKR_05212) 13122..13340 - 219 WP_006788213.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
OZE11_RS26210 (VKR_05213) 14051..16705 + 2655 WP_064169703.1 hypothetical protein -
OZE11_RS26215 (VKR_05214) 17023..18048 + 1026 WP_064169702.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..207699 207699


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11571.24 Da        Isoelectric Point: 6.4661

>T295035 WP_009309918.1 NZ_OV753635:c13120-12815 [Klebsiella quasipneumoniae]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVVPLASARLLSDKVSRELYPVVHIGDDSYRLMTTDMASVTASVTGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8362.31 Da        Isoelectric Point: 4.7405

>AT295035 WP_006788213.1 NZ_OV753635:c13340-13122 [Klebsiella quasipneumoniae]
MKQRITVTIDSDSYQLLKSADVNISGLVNRAMQNEARRLRAERWQAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H9GHC5

Antitoxin

Source ID Structure
AlphaFold DB A0A1D8K3R4

References