Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4789107..4789620 Replicon chromosome
Accession NZ_OV753634
Organism Klebsiella quasipneumoniae isolate BB1501

Toxin (Protein)


Gene name relE Uniprot ID A0A663BE04
Locus tag OZE11_RS23530 Protein ID WP_017900571.1
Coordinates 4789107..4789388 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag OZE11_RS23535 Protein ID WP_002886901.1
Coordinates 4789378..4789620 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OZE11_RS23515 (4784215) 4784215..4785870 + 1656 WP_004206514.1 alpha,alpha-phosphotrehalase -
OZE11_RS23520 (4786256) 4786256..4788394 + 2139 WP_004206513.1 anaerobic ribonucleoside-triphosphate reductase -
OZE11_RS23525 (4788639) 4788639..4789103 + 465 WP_094309610.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
OZE11_RS23530 (4789107) 4789107..4789388 - 282 WP_017900571.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OZE11_RS23535 (4789378) 4789378..4789620 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OZE11_RS23540 (4789698) 4789698..4791608 - 1911 WP_094309609.1 PRD domain-containing protein -
OZE11_RS23545 (4791631) 4791631..4792782 - 1152 WP_094309608.1 lactonase family protein -
OZE11_RS23550 (4792849) 4792849..4793589 - 741 WP_049003745.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(18-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11082.93 Da        Isoelectric Point: 10.4123

>T295034 WP_017900571.1 NZ_OV753634:c4789388-4789107 [Klebsiella quasipneumoniae]
MTYELEFDPRAWREWQLGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDRVVVVYVIAIGKR
EKAAVYHQANKRL

Download         Length: 282 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT295034 WP_002886901.1 NZ_OV753634:c4789620-4789378 [Klebsiella quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663BE04

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References