Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4719365..4719990 Replicon chromosome
Accession NZ_OV753634
Organism Klebsiella quasipneumoniae isolate BB1501

Toxin (Protein)


Gene name ykfI Uniprot ID A0A483YFJ1
Locus tag OZE11_RS23225 Protein ID WP_025987721.1
Coordinates 4719365..4719706 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag OZE11_RS23230 Protein ID WP_267668002.1
Coordinates 4719730..4719990 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OZE11_RS23210 (4716359) 4716359..4717594 - 1236 WP_139110622.1 hypothetical protein -
OZE11_RS23215 (4718019) 4718019..4718390 - 372 WP_227506902.1 hypothetical protein -
OZE11_RS23220 (4718417) 4718417..4719250 - 834 WP_040173641.1 DUF4942 domain-containing protein -
OZE11_RS23225 (4719365) 4719365..4719706 - 342 WP_025987721.1 TA system toxin CbtA family protein Toxin
OZE11_RS23230 (4719730) 4719730..4719990 - 261 WP_267668002.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
OZE11_RS23235 (4720066) 4720066..4721604 - 1539 WP_004181747.1 IS66 family transposase -
OZE11_RS23240 (4721654) 4721654..4722001 - 348 WP_004114612.1 IS66 family insertion sequence element accessory protein TnpB -
OZE11_RS23245 (4721998) 4721998..4722375 - 378 WP_004118218.1 transposase -
OZE11_RS23250 (4722517) 4722517..4722993 - 477 WP_019725273.1 DNA repair protein RadC -
OZE11_RS23255 (4723003) 4723003..4723449 - 447 WP_025987722.1 antirestriction protein -
OZE11_RS23260 (4723660) 4723660..4724349 - 690 WP_009309812.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4705149..4741150 36001


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-107)

Antitoxin

Antitoxin CbeA

(1-85)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12867.90 Da        Isoelectric Point: 8.5195

>T295033 WP_025987721.1 NZ_OV753634:c4719706-4719365 [Klebsiella quasipneumoniae]
MKTLPATIQRAAKPCPSPVTVWQMLLTRLLEQHYGLTLNDTPFSDETVIQEHINAGITLVDAVNFLVEKYELVRIDRRGF
NCQEQSPYLGAVDILRARQATGLLRQRHLPSIR

Download         Length: 342 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9805.15 Da        Isoelectric Point: 6.3146

>AT295033 WP_267668002.1 NZ_OV753634:c4719990-4719730 [Klebsiella quasipneumoniae]
MVQEGNRLHYLADRANITGKFGDAECLKLEEAFPHFIRQMELMLSTGELNPRHAHSVTLYHNAFTCEADTLGSCGYVYIV
IYPTQR

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483YFJ1

Antitoxin

Source ID Structure

References