Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2711288..2712876 Replicon chromosome
Accession NZ_OV753634
Organism Klebsiella quasipneumoniae isolate BB1501

Toxin (Protein)


Gene name hipA Uniprot ID A0A246AZS4
Locus tag OZE11_RS13435 Protein ID WP_017900381.1
Coordinates 2711288..2712610 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A2A5MFC9
Locus tag OZE11_RS13440 Protein ID WP_004205921.1
Coordinates 2712610..2712876 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OZE11_RS13400 (2706370) 2706370..2706588 + 219 WP_002904808.1 ParD-like family protein -
OZE11_RS13405 (2706569) 2706569..2707351 + 783 WP_049093365.1 type I methionyl aminopeptidase -
OZE11_RS13410 (2707620) 2707620..2708735 + 1116 WP_049093366.1 serine hydrolase domain-containing protein -
OZE11_RS13415 (2708722) 2708722..2709066 + 345 WP_004205915.1 hypothetical protein -
OZE11_RS13420 (2709095) 2709095..2709628 + 534 WP_004205916.1 hypothetical protein -
OZE11_RS13425 (2709631) 2709631..2709837 + 207 WP_004205917.1 helix-turn-helix transcriptional regulator -
OZE11_RS13430 (2709979) 2709979..2711271 + 1293 WP_096833914.1 glycoside hydrolase family 10 protein -
OZE11_RS13435 (2711288) 2711288..2712610 - 1323 WP_017900381.1 type II toxin-antitoxin system HipA family toxin Toxin
OZE11_RS13440 (2712610) 2712610..2712876 - 267 WP_004205921.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
OZE11_RS13445 (2713159) 2713159..2713485 - 327 WP_017900379.1 hydroxyisourate hydrolase -
OZE11_RS13450 (2713482) 2713482..2713982 - 501 WP_017900378.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
OZE11_RS13455 (2713960) 2713960..2715339 - 1380 WP_017900377.1 nucleobase:cation symporter-2 family protein -
OZE11_RS13460 (2715685) 2715685..2716839 + 1155 WP_004205928.1 FAD-dependent urate hydroxylase HpxO -
OZE11_RS13465 (2716820) 2716820..2717743 - 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49041.33 Da        Isoelectric Point: 8.6091

>T295031 WP_017900381.1 NZ_OV753634:c2712610-2711288 [Klebsiella quasipneumoniae]
MATLTTWMNNARVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRERIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLAALRWQTLDEAQLTALLTAYQSDIPLGMVTGQDDFRISVAGAQEKTAL
LRMGEHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARALGLAVPEAEIINTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILGEFADRVP
QAIESARRTLPSDFSAHVWRAITENMLKLHARLQQGLQAG

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9940.38 Da        Isoelectric Point: 7.1997

>AT295031 WP_004205921.1 NZ_OV753634:c2712876-2712610 [Klebsiella quasipneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQEALASRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKPAETAMIP
DNTTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A246AZS4

Antitoxin

Source ID Structure
AlphaFold DB A0A2A5MFC9

References