Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2041813..2042327 Replicon chromosome
Accession NZ_OV648025
Organism Staphylococcus argenteus isolate 20S00001-1_long

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7JQI0
Locus tag MD993_RS09675 Protein ID WP_000233591.1
Coordinates 2041813..2042022 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag MD993_RS09680 Protein ID WP_000138932.1
Coordinates 2042034..2042327 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MD993_RS09655 2037148..2038512 - 1365 WP_031787694.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
MD993_RS09660 2038527..2039597 - 1071 WP_031787695.1 D-alanine--D-alanine ligase -
MD993_RS09665 2039916..2041118 + 1203 WP_031787696.1 FtsW/RodA/SpoVE family cell cycle protein -
MD993_RS09670 2041547..2041684 - 138 WP_000828355.1 Lmo0850 family protein -
MD993_RS09675 2041813..2042022 - 210 WP_000233591.1 heavy metal-associated domain-containing protein Toxin
MD993_RS09680 2042034..2042327 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
MD993_RS09685 2042495..2043979 + 1485 WP_031787697.1 cardiolipin synthase -
MD993_RS09690 2044008..2044655 + 648 WP_031787698.1 HD domain-containing protein -
MD993_RS09695 2045250..2046119 - 870 WP_000725805.1 membrane protein insertase YidC -
MD993_RS09700 2046205..2046846 - 642 WP_031787699.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7827.81 Da        Isoelectric Point: 4.2681

>T295023 WP_000233591.1 NZ_OV648025:c2042022-2041813 [Staphylococcus argenteus]
MVHQNTIYTAGIETEEQVNQLTERISNMIGVHKVNINIIDGEVVVAYETPANLNSIEKEIYDTGYKIVY

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT295023 WP_000138932.1 NZ_OV648025:c2042327-2042034 [Staphylococcus argenteus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7JQI0

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References