295022

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2021677..2022206 Replicon chromosome
Accession NZ_OV648025
Organism Staphylococcus argenteus isolate 20S00001-1_long

Toxin (Protein)


Gene name mazF Uniprot ID A0A7U7JQG1
Locus tag MD993_RS09590 Protein ID WP_000621178.1
Coordinates 2021677..2022039 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag MD993_RS09595 Protein ID WP_000948331.1
Coordinates 2022036..2022206 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MD993_RS09570 2018659..2019429 - 771 WP_001041104.1 RNA polymerase sigma factor SigB -
MD993_RS09575 2019404..2019883 - 480 WP_001190826.1 anti-sigma B factor RsbW -
MD993_RS09580 2019885..2020211 - 327 WP_001052491.1 anti-sigma factor antagonist -
MD993_RS09585 2020328..2021329 - 1002 WP_000390825.1 PP2C family protein-serine/threonine phosphatase -
MD993_RS09590 2021677..2022039 - 363 WP_000621178.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MD993_RS09595 2022036..2022206 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MD993_RS09600 2022291..2023439 - 1149 WP_001281137.1 alanine racemase -
MD993_RS09605 2023509..2023868 - 360 WP_031787685.1 holo-ACP synthase -
MD993_RS09610 2023872..2024375 - 504 WP_031787686.1 PH domain-containing protein -
MD993_RS09615 2024362..2025945 - 1584 WP_031787687.1 PH domain-containing protein -
MD993_RS09620 2025938..2026417 - 480 WP_031787688.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13502.79 Da        Isoelectric Point: 10.2892

>T295022 WP_000621178.1 NZ_OV648025:c2022039-2021677 [Staphylococcus argenteus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDNKMKEVDNALMISLGLNTMAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT295022 WP_000948331.1 NZ_OV648025:c2022206-2022036 [Staphylococcus argenteus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7JQG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References