295021

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1858944..1859731 Replicon chromosome
Accession NZ_OV648025
Organism Staphylococcus argenteus isolate 20S00001-1_long

Toxin (Protein)


Gene name tsbT Uniprot ID A0A7U7PZK3
Locus tag MD993_RS08660 Protein ID WP_000031103.1
Coordinates 1858944..1859099 (-) Length 52 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A7U7JVF2
Locus tag MD993_RS08665 Protein ID WP_047430475.1
Coordinates 1859132..1859731 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MD993_RS08640 1854132..1855244 - 1113 WP_031787927.1 GAF domain-containing sensor histidine kinase -
MD993_RS08645 1855406..1856227 + 822 WP_000669386.1 RluA family pseudouridine synthase -
MD993_RS08650 1856521..1857906 - 1386 WP_031787928.1 class II fumarate hydratase -
MD993_RS08655 1858077..1858478 - 402 WP_000901017.1 hypothetical protein -
MD993_RS08660 1858944..1859099 - 156 WP_000031103.1 SAS053 family protein Toxin
MD993_RS08665 1859132..1859731 - 600 WP_047430475.1 glucosamine-6-phosphate isomerase Antitoxin
MD993_RS08670 1859890..1860360 - 471 WP_000181399.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MD993_RS08675 1860362..1861492 - 1131 WP_031787930.1 tRNA epoxyqueuosine(34) reductase QueG -
MD993_RS08680 1861643..1862365 - 723 WP_031787931.1 amino acid ABC transporter ATP-binding protein -
MD993_RS08685 1862358..1863815 - 1458 WP_000649887.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 52 a.a.        Molecular weight: 6019.42 Da        Isoelectric Point: 4.1469

>T295021 WP_000031103.1 NZ_OV648025:c1859099-1858944 [Staphylococcus argenteus]
MSKDKDAKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKSTDEKNSH

Download         Length: 156 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22438.57 Da        Isoelectric Point: 5.3935

>AT295021 WP_047430475.1 NZ_OV648025:c1859731-1859132 [Staphylococcus argenteus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDNKKSYFEALGV
PASQIYPIAFEKDAIEFISDKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKKEVVEKLYQENGK
TSFEPSDLKSHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7PZK3

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7JVF2

References