Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4821614..4822130 Replicon chromosome
Accession NZ_OV408202
Organism Klebsiella pneumoniae isolate CNR146C9

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag NBX86_RS23360 Protein ID WP_004178374.1
Coordinates 4821614..4821898 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A919M0P8
Locus tag NBX86_RS23365 Protein ID WP_032434351.1
Coordinates 4821888..4822130 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBX86_RS23335 (4817097) 4817097..4817405 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
NBX86_RS23340 (4817490) 4817490..4817663 + 174 WP_032414379.1 hypothetical protein -
NBX86_RS23345 (4817666) 4817666..4818409 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
NBX86_RS23350 (4818766) 4818766..4820904 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
NBX86_RS23355 (4821146) 4821146..4821610 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NBX86_RS23360 (4821614) 4821614..4821898 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NBX86_RS23365 (4821888) 4821888..4822130 - 243 WP_032434351.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NBX86_RS23370 (4822208) 4822208..4824118 - 1911 WP_004152270.1 PRD domain-containing protein -
NBX86_RS23375 (4824141) 4824141..4825295 - 1155 WP_002886900.1 lactonase family protein -
NBX86_RS23380 (4825361) 4825361..4826101 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-68)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T295015 WP_004178374.1 NZ_OV408202:c4821898-4821614 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9003.47 Da        Isoelectric Point: 6.3340

>AT295015 WP_032434351.1 NZ_OV408202:c4822130-4821888 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGGKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure

References