Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4728886..4729589 Replicon chromosome
Accession NZ_OV408202
Organism Klebsiella pneumoniae isolate CNR146C9

Toxin (Protein)


Gene name ykfI Uniprot ID A0A939NMR5
Locus tag NBX86_RS22970 Protein ID WP_071994632.1
Coordinates 4728886..4729227 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A939NIK9
Locus tag NBX86_RS22975 Protein ID WP_032434296.1
Coordinates 4729248..4729589 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBX86_RS22960 (4725201) 4725201..4726070 + 870 WP_023317468.1 HNH endonuclease -
NBX86_RS22965 (4726661) 4726661..4728694 + 2034 WP_050598589.1 hypothetical protein -
NBX86_RS22970 (4728886) 4728886..4729227 - 342 WP_071994632.1 TA system toxin CbtA family protein Toxin
NBX86_RS22975 (4729248) 4729248..4729589 - 342 WP_032434296.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NBX86_RS22980 (4729600) 4729600..4730142 - 543 WP_032434298.1 DNA repair protein RadC -
NBX86_RS22985 (4730155) 4730155..4730595 - 441 WP_032434300.1 antirestriction protein -
NBX86_RS22990 (4730626) 4730626..4731447 - 822 WP_032434301.1 DUF932 domain-containing protein -
NBX86_RS22995 (4731567) 4731567..4732040 - 474 WP_032434303.1 hypothetical protein -
NBX86_RS23000 (4732112) 4732112..4732564 - 453 WP_032410767.1 hypothetical protein -
NBX86_RS23005 (4732600) 4732600..4733316 - 717 WP_032434305.1 WYL domain-containing protein -
NBX86_RS23010 (4733560) 4733560..4734434 - 875 Protein_4516 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4717183..4762856 45673


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12789.77 Da        Isoelectric Point: 9.6552

>T295014 WP_071994632.1 NZ_OV408202:c4729227-4728886 [Klebsiella pneumoniae]
MKTLPATTPQAVTLCLSSVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRKGF
NWQEHSPYLRAVDILRARQATGLLRRSRKNAVR

Download         Length: 342 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12893.40 Da        Isoelectric Point: 5.9612

>AT295014 WP_032434296.1 NZ_OV408202:c4729589-4729248 [Klebsiella pneumoniae]
MKSTDSENDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGEFSNAESLKLDEVFPHFISQMESMLTTGEMNPRH
AHFFTLYHNGFTCEADTLGSYGYVYIAVYPTQR

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References