Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2732689..2734277 Replicon chromosome
Accession NZ_OV408202
Organism Klebsiella pneumoniae isolate CNR146C9

Toxin (Protein)


Gene name hipA Uniprot ID A0A9J6RYF8
Locus tag NBX86_RS13335 Protein ID WP_004892016.1
Coordinates 2732689..2734011 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NBX86_RS13340 Protein ID WP_004176198.1
Coordinates 2734011..2734277 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBX86_RS13320 (2727745) 2727745..2730246 + 2502 WP_032435337.1 fimbria/pilus outer membrane usher protein -
NBX86_RS13325 (2730234) 2730234..2731238 + 1005 WP_032435338.1 fimbrial protein -
NBX86_RS13330 (2731380) 2731380..2732672 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NBX86_RS13335 (2732689) 2732689..2734011 - 1323 WP_004892016.1 type II toxin-antitoxin system HipA family toxin Toxin
NBX86_RS13340 (2734011) 2734011..2734277 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NBX86_RS13345 (2734664) 2734664..2734990 - 327 WP_004184023.1 hydroxyisourate hydrolase -
NBX86_RS13350 (2734987) 2734987..2735487 - 501 WP_032435339.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NBX86_RS13355 (2735465) 2735465..2736844 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
NBX86_RS13360 (2737190) 2737190..2738344 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
NBX86_RS13365 (2738325) 2738325..2739248 - 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49141.44 Da        Isoelectric Point: 7.5357

>T295011 WP_004892016.1 NZ_OV408202:c2734011-2732689 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT295011 WP_004176198.1 NZ_OV408202:c2734277-2734011 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References