Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 3409468..3411116 Replicon chromosome
Accession NZ_OV350343
Organism Halomonas sp. TD01 strain Halomonas Bluephagenesis

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag L1X57_RS15405 Protein ID WP_039869607.1
Coordinates 3409770..3411116 (-) Length 449 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag L1X57_RS15400 Protein ID WP_009724376.1
Coordinates 3409468..3409773 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1X57_RS15390 (HPTD01_3167) 3406204..3407412 + 1209 WP_009724378.1 lipocalin-like domain-containing protein -
L1X57_RS15395 (HPTD01_3168) 3407704..3409437 + 1734 WP_009724377.1 PilZ domain-containing protein -
L1X57_RS15400 (HPTD01_3169) 3409468..3409773 - 306 WP_009724376.1 helix-turn-helix domain-containing protein Antitoxin
L1X57_RS15405 (HPTD01_3170) 3409770..3411116 - 1347 WP_039869607.1 HipA domain-containing protein Toxin
L1X57_RS15410 (HPTD01_3171) 3411264..3411611 + 348 WP_009724374.1 hypothetical protein -
L1X57_RS15415 (HPTD01_3172) 3411736..3412515 + 780 WP_009724373.1 transporter substrate-binding domain-containing protein -
L1X57_RS15420 (HPTD01_3174) 3413242..3413679 - 438 WP_009724372.1 LysR substrate-binding domain-containing protein -
L1X57_RS15425 (HPTD01_3175) 3414111..3414998 + 888 WP_009724371.1 FRG domain-containing protein -
L1X57_RS15430 3414970..3415317 - 348 WP_009724370.1 abortive infection family protein -
L1X57_RS15435 (HPTD01_3176) 3415456..3415713 - 258 WP_009724369.1 hypothetical protein -
L1X57_RS15440 (HPTD01_3177) 3415813..3416031 - 219 WP_009724368.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-404)

Antitoxin

Cro/C1-type helix-turn-helix domain

(28-86)


Sequences

Toxin        


Download         Length: 449 a.a.        Molecular weight: 50779.70 Da        Isoelectric Point: 4.9323

>T295002 WP_039869607.1 NZ_OV350343:c3411116-3409770 [Halomonas sp. TD01]
MKLTIQVHFDQAWHDAAELSLPNPEQGTRGESRLRYATDYAVEWLFQDDLRACSMRLPIELMLTHESPHWFGFLEDIMPA
GASRRFWVDYLGLHDLPVGRQDAELLARGTIAPVGNLRIKESVPDLSAKKALEERRFPVQSVVERQVDFLEYAQQMGAAS
GGATGAGGEAPKLLLRMTNDDHVWIDTWQDENHRPDLPMLVKFPRGKRSADDCDILRAEYHYYQELASLGVATIDTERMR
LEEGERYPSLWLPRFDMQYLDGTWVRYGLESVYSLVGAAPGTFLHHGDTIRQLISLLGAQYRVQEQGAVFESDLFVLEWI
KRDLLNIAFGNSDNHGRNTALLKRPEGIGFAPVYDFAPMKADPEGVTRTTQWGTPLEVGGEYDWLAIADTLSDIVEPERV
IEELRALALKLKGVDERLADRGVPPRILDMPAVGLRTINTRLKRWGLL

Download         Length: 1347 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11488.31 Da        Isoelectric Point: 10.2690

>AT295002 WP_009724376.1 NZ_OV350343:c3409773-3409468 [Halomonas sp. TD01]
MKRGYSDDREEALVALLKRFYAGEITDGALLRALRRDVLGLNQTRYAALVGISRRTLSDLEGDKNNVTLEVKNRVFRPLG
LEVSLLPRKRALLEQILTFTE

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References