Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1741295..1742853 Replicon chromosome
Accession NZ_OV100759
Organism Aggregatibacter sp. Marseille-P9115

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag LQ983_RS08395 Protein ID WP_230622335.1
Coordinates 1741295..1742575 (-) Length 427 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag LQ983_RS08400 Protein ID WP_230622336.1
Coordinates 1742575..1742853 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ983_RS08375 1736625..1737071 + 447 WP_230622331.1 DNA polymerase III subunit chi -
LQ983_RS08380 1737150..1737461 + 312 WP_230622332.1 N(4)-acetylcytidine aminohydrolase -
LQ983_RS08385 1737477..1738325 + 849 WP_230622333.1 hypothetical protein -
LQ983_RS08390 1738348..1741212 + 2865 WP_230622334.1 valine--tRNA ligase -
LQ983_RS08395 1741295..1742575 - 1281 WP_230622335.1 type II toxin-antitoxin system HipA family toxin Toxin
LQ983_RS08400 1742575..1742853 - 279 WP_230622336.1 helix-turn-helix domain-containing protein Antitoxin
LQ983_RS08405 1743008..1744063 - 1056 WP_230622337.1 ABC transporter substrate-binding protein -
LQ983_RS08410 1744316..1745830 - 1515 WP_230622338.1 DHA2 family efflux MFS transporter permease subunit -
LQ983_RS08415 1745843..1747003 - 1161 WP_230622339.1 EmrA/EmrK family multidrug efflux transporter periplasmic adaptor subunit -
LQ983_RS08420 1747194..1747676 + 483 WP_230622340.1 Dps family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(148-393)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-64)


Sequences

Toxin        


Download         Length: 427 a.a.        Molecular weight: 49177.56 Da        Isoelectric Point: 7.9883

>T294997 WP_230622335.1 NZ_OV100759:c1742575-1741295 [Aggregatibacter sp. Marseille-P9115]
MSNSILNVAMNGLLVGEWRKLTSGATEFQYAEKWLESVRSRPISLSLPLSHKIYRGDSVYNFFDNLLPDNEQIRSRIQQR
FQTSTKSPFDLLSAIGQDCIGAIQLYQGQSLSVRQIYAEPLNDKEVENVLKNYRTFPLGMEESEDFRISLAGAQEKTALL
YYQNQWQRPLHSTATSHIFKLPIGMVAQGQLDLSGSCENEWLCLNIMKAFGLPVPRSQIQYFGEMKVLIVERFDRRWSEN
RSWLIRLPQEDMCQALNIAPARKYENDGGPSILQIMSLLNGSSNAQADRKQFFKAQIIFWLLCAIDGHGKNFSLFLEQEN
RYRLTPFYDVMSAYPLIKHNGLQKQKVKMAMAWHGENKHYLWDKIQLRHLFNTAKLTGLAKETVEDILHEICALYPRVSE
INTHRLPDEIVEPIFMGLEMQMKKIG

Download         Length: 1281 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10428.86 Da        Isoelectric Point: 4.8605

>AT294997 WP_230622336.1 NZ_OV100759:c1742853-1742575 [Aggregatibacter sp. Marseille-P9115]
MVITTAKMLSHVIREFRYQGELSQTDVAKLAGTTQARISAFENEPERTKLETLFKILAGLELELIVQPRKKSSDTNLSIK
EPTATYDDDEAW

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References