Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 172458..173083 Replicon chromosome
Accession NZ_OV100759
Organism Aggregatibacter sp. Marseille-P9115

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LQ983_RS00765 Protein ID WP_111277555.1
Coordinates 172901..173083 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LQ983_RS00760 Protein ID WP_230621289.1
Coordinates 172458..172871 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ983_RS00745 169334..169831 + 498 WP_111305910.1 5-(carboxyamino)imidazole ribonucleotide mutase -
LQ983_RS00750 169971..171059 + 1089 WP_230621288.1 5-(carboxyamino)imidazole ribonucleotide synthase -
LQ983_RS00755 171149..172339 + 1191 WP_109842775.1 amino acid aminotransferase -
LQ983_RS00760 172458..172871 - 414 WP_230621289.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LQ983_RS00765 172901..173083 - 183 WP_111277555.1 type II toxin-antitoxin system HicA family toxin Toxin
LQ983_RS00770 173472..174458 + 987 WP_230621290.1 iron ABC transporter permease -
LQ983_RS00775 174468..175256 + 789 WP_230621291.1 ABC transporter ATP-binding protein -
LQ983_RS00780 175269..176303 + 1035 WP_230621292.1 ABC transporter substrate-binding protein -
LQ983_RS00785 176392..176601 + 210 WP_006718235.1 TOBE domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-130)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6883.09 Da        Isoelectric Point: 10.8207

>T294995 WP_111277555.1 NZ_OV100759:c173083-172901 [Aggregatibacter sp. Marseille-P9115]
VDSRKIIKMIEADGWIFHHATGSHYHFTHPIKKGIVTVPHPKKDLKKGTENSILKQARLK

Download         Length: 183 bp

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15114.24 Da        Isoelectric Point: 4.6216

>AT294995 WP_230621289.1 NZ_OV100759:c172871-172458 [Aggregatibacter sp. Marseille-P9115]
MLYPIAIEPGDETHAFGVIVPDIPGCFSAGDTLEEAYTNAKAAIAGHLELLVEMGEEVPLPTSMENHRNNPDFTNYGMFF
GVVDVDITHLLGKSEKINITMPAYLIKRIDDFVSTHREYKNRSSFLAKIAADKILSA

Download         Length: 414 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References