Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 5019656..5021244 Replicon chromosome
Accession NZ_OV049808
Organism Klebsiella pneumoniae strain DJ isolate DJ

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag LRA90_RS24605 Protein ID WP_002904792.1
Coordinates 5019656..5020978 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag LRA90_RS24610 Protein ID WP_002904790.1
Coordinates 5020978..5021244 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRA90_RS24590 (5014712) 5014712..5017213 + 2502 WP_032433099.1 fimbria/pilus outer membrane usher protein -
LRA90_RS24595 (5017201) 5017201..5018205 + 1005 WP_032433097.1 fimbrial protein -
LRA90_RS24600 (5018347) 5018347..5019639 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
LRA90_RS24605 (5019656) 5019656..5020978 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
LRA90_RS24610 (5020978) 5020978..5021244 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
LRA90_RS24615 (5021630) 5021630..5021956 - 327 WP_002904788.1 hydroxyisourate hydrolase -
LRA90_RS24620 (5021953) 5021953..5022453 - 501 WP_032433095.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
LRA90_RS24625 (5022431) 5022431..5023810 - 1380 WP_032433093.1 nucleobase:cation symporter-2 family protein -
LRA90_RS24630 (5024156) 5024156..5025310 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
LRA90_RS24635 (5025291) 5025291..5026214 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element rmtF / ARR-3 / blaNDM-5 / sul1 mgtC / iroE 4827972..5074080 246108


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T294988 WP_002904792.1 NZ_OV049808:c5020978-5019656 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT294988 WP_002904790.1 NZ_OV049808:c5021244-5020978 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References