Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3699315..3700051 Replicon chromosome
Accession NZ_OV049808
Organism Klebsiella pneumoniae strain DJ isolate DJ

Toxin (Protein)


Gene name tacT Uniprot ID A0A4S4Y1H2
Locus tag LRA90_RS18040 Protein ID WP_032433360.1
Coordinates 3699569..3700051 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag LRA90_RS18035 Protein ID WP_003026799.1
Coordinates 3699315..3699581 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRA90_RS18010 (3694961) 3694961..3696100 + 1140 WP_230633508.1 mannitol dehydrogenase -
LRA90_RS18015 (3696129) 3696129..3696791 + 663 WP_032433366.1 dihydroxyacetone kinase subunit DhaL -
LRA90_RS18020 (3696775) 3696775..3697779 + 1005 WP_032433364.1 dihydroxyacetone kinase subunit DhaK -
LRA90_RS18025 (3697797) 3697797..3698429 + 633 WP_032433362.1 3-hexulose-6-phosphate synthase -
LRA90_RS18030 (3698439) 3698439..3699002 + 564 WP_032433361.1 6-phospho-3-hexuloisomerase -
LRA90_RS18035 (3699315) 3699315..3699581 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
LRA90_RS18040 (3699569) 3699569..3700051 + 483 WP_032433360.1 GNAT family N-acetyltransferase Toxin
LRA90_RS18045 (3700412) 3700412..3700960 - 549 WP_230633509.1 helix-turn-helix transcriptional regulator -
LRA90_RS18050 (3701222) 3701222..3702166 - 945 WP_077254249.1 fimbrial protein -
LRA90_RS18055 (3702178) 3702178..3702756 - 579 WP_032432061.1 type 1 fimbrial protein -
LRA90_RS18060 (3702760) 3702760..3703500 - 741 WP_050597964.1 molecular chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3669538..3710991 41453


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(72-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17421.02 Da        Isoelectric Point: 9.6047

>T294983 WP_032433360.1 NZ_OV049808:3699569-3700051 [Klebsiella pneumoniae]
VGRVTAPEPLSSSHQLAEFVSGETVLDEWLKHRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTETTGRLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYTHHGFTASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT294983 WP_003026799.1 NZ_OV049808:3699315-3699581 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S4Y1H2

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References