Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 3682624..3683267 Replicon chromosome
Accession NZ_OV049808
Organism Klebsiella pneumoniae strain DJ isolate DJ

Toxin (Protein)


Gene name vagD Uniprot ID A0A4S8C081
Locus tag LRA90_RS17945 Protein ID WP_032433387.1
Coordinates 3682851..3683267 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag LRA90_RS17940 Protein ID WP_001261276.1
Coordinates 3682624..3682854 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRA90_RS17925 (3677646) 3677646..3678733 + 1088 Protein_3480 transcriptional regulator -
LRA90_RS17930 (3678736) 3678736..3680976 + 2241 WP_045326788.1 P-loop NTPase fold protein -
LRA90_RS17935 (3681504) 3681504..3682319 - 816 WP_032433388.1 hypothetical protein -
LRA90_RS17940 (3682624) 3682624..3682854 + 231 WP_001261276.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LRA90_RS17945 (3682851) 3682851..3683267 + 417 WP_032433387.1 type II toxin-antitoxin system VapC family toxin Toxin
LRA90_RS17950 (3683423) 3683423..3684403 + 981 WP_032433385.1 hypothetical protein -
LRA90_RS17955 (3684598) 3684598..3686169 - 1572 WP_032433383.1 AAA family ATPase -
LRA90_RS17960 (3686488) 3686488..3686736 + 249 WP_032433382.1 hypothetical protein -
LRA90_RS17965 (3686795) 3686795..3687313 + 519 WP_045326794.1 hypothetical protein -
LRA90_RS17970 (3687344) 3687344..3687835 + 492 WP_032433378.1 hypothetical protein -
LRA90_RS17975 (3687895) 3687895..3688098 + 204 WP_032433376.1 HHA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3669538..3710991 41453


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14974.43 Da        Isoelectric Point: 7.8921

>T294982 WP_032433387.1 NZ_OV049808:3682851-3683267 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALHLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLTLEDWVI

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT294982 WP_001261276.1 NZ_OV049808:3682624-3682854 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S8C081

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References