Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3022420..3023077 Replicon chromosome
Accession NZ_OV049808
Organism Klebsiella pneumoniae strain DJ isolate DJ

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LRA90_RS14690 Protein ID WP_002916310.1
Coordinates 3022667..3023077 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LRA90_RS14685 Protein ID WP_002916312.1
Coordinates 3022420..3022686 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRA90_RS14660 (3017576) 3017576..3019009 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
LRA90_RS14665 (3019128) 3019128..3019856 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LRA90_RS14670 (3019906) 3019906..3020217 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
LRA90_RS14675 (3020381) 3020381..3021040 + 660 WP_002916317.1 hemolysin III family protein -
LRA90_RS14680 (3021191) 3021191..3022174 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
LRA90_RS14685 (3022420) 3022420..3022686 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LRA90_RS14690 (3022667) 3022667..3023077 + 411 WP_002916310.1 protein YgfX Toxin
LRA90_RS14695 (3023084) 3023084..3023605 - 522 WP_004144730.1 flavodoxin FldB -
LRA90_RS14700 (3023706) 3023706..3024602 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LRA90_RS14705 (3024625) 3024625..3025338 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LRA90_RS14710 (3025344) 3025344..3027077 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T294981 WP_002916310.1 NZ_OV049808:3022667-3023077 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT294981 WP_002916312.1 NZ_OV049808:3022420-3022686 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References