Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 2098992..2099617 Replicon chromosome
Accession NZ_OV049808
Organism Klebsiella pneumoniae strain DJ isolate DJ

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag LRA90_RS10070 Protein ID WP_002882817.1
Coordinates 2098992..2099375 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag LRA90_RS10075 Protein ID WP_004150355.1
Coordinates 2099375..2099617 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRA90_RS10055 (2096358) 2096358..2097260 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
LRA90_RS10060 (2097257) 2097257..2097892 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
LRA90_RS10065 (2097889) 2097889..2098818 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
LRA90_RS10070 (2098992) 2098992..2099375 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
LRA90_RS10075 (2099375) 2099375..2099617 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
LRA90_RS10080 (2099822) 2099822..2100739 + 918 WP_021466676.1 alpha/beta hydrolase -
LRA90_RS10085 (2100753) 2100753..2101694 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
LRA90_RS10090 (2101739) 2101739..2102176 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
LRA90_RS10095 (2102173) 2102173..2103033 - 861 WP_004146232.1 virulence factor BrkB family protein -
LRA90_RS10100 (2103027) 2103027..2103626 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T294978 WP_002882817.1 NZ_OV049808:c2099375-2098992 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT294978 WP_004150355.1 NZ_OV049808:c2099617-2099375 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References