Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1608372..1608888 Replicon chromosome
Accession NZ_OV049808
Organism Klebsiella pneumoniae strain DJ isolate DJ

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag LRA90_RS07720 Protein ID WP_009486548.1
Coordinates 1608372..1608656 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LRA90_RS07725 Protein ID WP_002886901.1
Coordinates 1608646..1608888 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRA90_RS07695 (1603789) 1603789..1604052 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
LRA90_RS07700 (1604182) 1604182..1604355 + 174 WP_032433782.1 hypothetical protein -
LRA90_RS07705 (1604358) 1604358..1605101 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LRA90_RS07710 (1605458) 1605458..1607596 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
LRA90_RS07715 (1607904) 1607904..1608368 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LRA90_RS07720 (1608372) 1608372..1608656 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LRA90_RS07725 (1608646) 1608646..1608888 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LRA90_RS07730 (1608966) 1608966..1610876 - 1911 WP_009486549.1 PRD domain-containing protein -
LRA90_RS07735 (1610899) 1610899..1612053 - 1155 WP_002886900.1 lactonase family protein -
LRA90_RS07740 (1612120) 1612120..1612860 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T294977 WP_009486548.1 NZ_OV049808:c1608656-1608372 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT294977 WP_002886901.1 NZ_OV049808:c1608888-1608646 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References