Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1673374..1673963 Replicon chromosome
Accession NZ_OV040719
Organism Haemophilus influenzae strain 3655 isolate 3655

Toxin (Protein)


Gene name hicA Uniprot ID Q4QL51
Locus tag LSO74_RS08440 Protein ID WP_005653200.1
Coordinates 1673715..1673963 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q4QL50
Locus tag LSO74_RS08435 Protein ID WP_005653201.1
Coordinates 1673374..1673718 (-) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LSO74_RS08420 (KRLU3655_LOCUS1593) 1668597..1669991 - 1395 WP_005657016.1 sodium-coupled multidrug efflux MATE transporter HmrM -
LSO74_RS08425 (KRLU3655_LOCUS1594) 1670035..1670649 + 615 WP_005657019.1 riboflavin synthase -
LSO74_RS08430 (KRLU3655_LOCUS1595) 1670721..1673330 - 2610 WP_005657022.1 aminopeptidase N -
LSO74_RS08435 (KRLU3655_LOCUS1596) 1673374..1673718 - 345 WP_005653201.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LSO74_RS08440 (KRLU3655_LOCUS1597) 1673715..1673963 - 249 WP_005653200.1 type II toxin-antitoxin system HicA family toxin Toxin
LSO74_RS08445 (KRLU3655_LOCUS1598) 1674382..1674876 + 495 WP_005653194.1 5-(carboxyamino)imidazole ribonucleotide mutase -
LSO74_RS08450 (KRLU3655_LOCUS1599) 1674946..1676034 + 1089 WP_005657028.1 5-(carboxyamino)imidazole ribonucleotide synthase -
LSO74_RS08455 (KRLU3655_LOCUS1600) 1676174..1677364 + 1191 WP_005657030.1 amino acid aminotransferase -
LSO74_RS08460 1677449..1677576 - 128 Protein_1619 hydrogenase expression/formation protein HypE -
LSO74_RS08465 (KRLU3655_LOCUS1601) 1677586..1678203 - 618 WP_005657032.1 energy-coupling factor ABC transporter ATP-binding protein -
LSO74_RS08470 (KRLU3655_LOCUS1602) 1678205..1678837 - 633 WP_005657034.1 energy-coupling factor transporter transmembrane component T -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-102)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9425.93 Da        Isoelectric Point: 10.4673

>T294974 WP_005653200.1 NZ_OV040719:c1673963-1673715 [Haemophilus influenzae]
MGRTEKLLDKLAQSKSTFNWNELVSLLAQQGYEKREMAGSRVRFYNRTLEHTILLHKPHPENYIKGGALKSVKESLKQVG
IL

Download         Length: 249 bp

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13142.04 Da        Isoelectric Point: 4.8151

>AT294974 WP_005653201.1 NZ_OV040719:c1673718-1673374 [Haemophilus influenzae]
MKLLNYKGYVGTIEADLENNILFGKLAYIRDLVTYEAESLSELEKEFRQSVDLYLQDCLELGKEPNKPFKGVFNVRIGEE
LHREATIIAGDRSLNAFVTEAIQEKIFREKPSLR

Download         Length: 345 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5M6BP03

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GMF9

References