Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 764865..765502 Replicon chromosome
Accession NZ_OV040719
Organism Haemophilus influenzae strain 3655 isolate 3655

Toxin (Protein)


Gene name VapC1 Uniprot ID A0A0H3PFA4
Locus tag LSO74_RS04020 Protein ID WP_005656317.1
Coordinates 764865..765269 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID A0A0H3PN67
Locus tag LSO74_RS04025 Protein ID WP_005656316.1
Coordinates 765266..765502 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LSO74_RS03990 (KRLU3655_LOCUS754) 760426..760992 + 567 WP_005544066.1 elongation factor P -
LSO74_RS04000 (KRLU3655_LOCUS755) 761340..761930 - 591 WP_005656319.1 primosomal replication protein -
LSO74_RS04005 (KRLU3655_LOCUS756) 761963..763315 - 1353 WP_005649062.1 Na+/H+ antiporter family protein -
LSO74_RS04010 (KRLU3655_LOCUS757) 763629..764318 - 690 WP_005654067.1 ribonuclease T -
LSO74_RS04015 (KRLU3655_LOCUS758) 764392..764799 - 408 WP_005656318.1 lactoylglutathione lyase -
LSO74_RS04020 (KRLU3655_LOCUS759) 764865..765269 - 405 WP_005656317.1 type II toxin-antitoxin system VapC family toxin Toxin
LSO74_RS04025 (KRLU3655_LOCUS760) 765266..765502 - 237 WP_005656316.1 antitoxin Antitoxin
LSO74_RS04030 (KRLU3655_LOCUS761) 765595..766320 - 726 WP_005656315.1 carboxy-S-adenosyl-L-methionine synthase CmoA -
LSO74_RS04035 (KRLU3655_LOCUS762) 766373..766891 - 519 WP_005656314.1 isoprenylcysteine carboxyl methyltransferase family protein -
LSO74_RS04040 (KRLU3655_LOCUS763) 767110..768876 + 1767 WP_005656313.1 aspartate--tRNA ligase -
LSO74_RS04045 (KRLU3655_LOCUS764) 768898..769374 + 477 WP_005656312.1 dihydroneopterin triphosphate diphosphatase -
LSO74_RS04050 (KRLU3655_LOCUS765) 769534..770274 + 741 WP_005649034.1 YebC/PmpR family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

SpoVT-AbrB domain

(6-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15660.23 Da        Isoelectric Point: 8.9777

>T294972 WP_005656317.1 NZ_OV040719:c765269-764865 [Haemophilus influenzae]
MIYMLDTNIIIYLMKNRPKIVAERVSQLLPNDRLVISFLTYAELIKGAFGSQNYEQSIRAIELLTERVNVLYPNEQICLH
YGKWANTLKKQGRPIGNNDLWIACHALSLNAVLITHNVKEFQRITDLQWQDWTK

Download         Length: 405 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9007.16 Da        Isoelectric Point: 4.2342

>AT294972 WP_005656316.1 NZ_OV040719:c765502-765266 [Haemophilus influenzae]
MLAKVFQSGNSQAVRIPMDFRFDVDTVEIFRKENGDVVLRPVSKKTDDFLALFEGFDETFIQALEARDDLPPQERENL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3PFA4

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3PN67

References