294971

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 628552..629030 Replicon chromosome
Accession NZ_OV040719
Organism Haemophilus influenzae strain 3655 isolate 3655

Toxin (Protein)


Gene name VapD Uniprot ID A0A0H3PEZ5
Locus tag LSO74_RS03285 Protein ID WP_005656500.1
Coordinates 628752..629030 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID A0A0M1GIA6
Locus tag LSO74_RS03280 Protein ID WP_005649350.1
Coordinates 628552..628743 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LSO74_RS03255 (KRLU3655_LOCUS612) 624131..624763 + 633 WP_005656505.1 dTMP kinase -
LSO74_RS03260 (KRLU3655_LOCUS613) 624760..625743 + 984 WP_005659773.1 DNA polymerase III subunit delta' -
LSO74_RS03265 (KRLU3655_LOCUS614) 625798..626580 + 783 WP_005656503.1 YchF/TatD family DNA exonuclease -
LSO74_RS03270 (KRLU3655_LOCUS615) 626607..627131 + 525 WP_005656502.1 DUF1523 family protein -
LSO74_RS03275 (KRLU3655_LOCUS616) 627182..628480 + 1299 WP_032821894.1 hemolysin family protein -
LSO74_RS03280 (KRLU3655_LOCUS617) 628552..628743 + 192 WP_005649350.1 DUF5397 domain-containing protein Antitoxin
LSO74_RS03285 (KRLU3655_LOCUS618) 628752..629030 + 279 WP_005656500.1 virulence-associated protein VapD Toxin
LSO74_RS03290 (KRLU3655_LOCUS619) 629123..629653 + 531 WP_005656499.1 hypothetical protein -
LSO74_RS03295 (KRLU3655_LOCUS620) 629725..631224 + 1500 WP_005656498.1 fused PTS fructose transporter subunit IIA/HPr protein -
LSO74_RS03300 (KRLU3655_LOCUS621) 631226..632167 + 942 WP_005656497.1 1-phosphofructokinase -
LSO74_RS03305 (KRLU3655_LOCUS622) 632169..633839 + 1671 WP_005656496.1 fructose-specific PTS transporter subunit EIIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(1-63)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.09 Da        Isoelectric Point: 5.7408

>T294971 WP_005656500.1 NZ_OV040719:628752-629030 [Haemophilus influenzae]
MYAIAFDLVVKDTQDYHPKGVQQAYTDIGAVLAKFGFVRTQGSLYTNMNEDMANLFQAMNALKQLAWISQSVRDIRAFRI
EQWSDFTDFIRN

Download         Length: 279 bp

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7047.02 Da        Isoelectric Point: 3.9930

>AT294971 WP_005649350.1 NZ_OV040719:628552-628743 [Haemophilus influenzae]
MELRQQIPTGCIKQFGQFGVPYVVGEVAEFLPDGDVLVNITLLQSGEKDIYRLSHLLEDPEAE

Download         Length: 192 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3PEZ5

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GIA6

References