Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) toxTA/Tad-couple_hipB
Location 369528..370038 Replicon chromosome
Accession NZ_OV040719
Organism Haemophilus influenzae strain 3655 isolate 3655

Toxin (Protein)


Gene name toxT Uniprot ID A0A0H3PB74
Locus tag LSO74_RS01865 Protein ID WP_005658624.1
Coordinates 369528..369749 (+) Length 74 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag LSO74_RS01870 Protein ID WP_005650837.1
Coordinates 369742..370038 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LSO74_RS01855 (KRLU3655_LOCUS359) 366426..366608 + 183 WP_231052467.1 PT domain-containing protein -
LSO74_RS01860 (KRLU3655_LOCUS360) 366544..369421 + 2878 Protein_362 TonB-dependent hemoglobin/transferrin/lactoferrin family receptor -
LSO74_RS01865 369528..369749 + 222 WP_005658624.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LSO74_RS01870 (KRLU3655_LOCUS361) 369742..370038 + 297 WP_005650837.1 helix-turn-helix transcriptional regulator Antitoxin
LSO74_RS01875 (KRLU3655_LOCUS362) 370205..372121 + 1917 WP_005658626.1 ABC transporter ATP-binding protein -
LSO74_RS01880 (KRLU3655_LOCUS363) 372131..372667 + 537 WP_053521035.1 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
LSO74_RS01885 (KRLU3655_LOCUS364) 372683..373234 + 552 WP_005658631.1 Sua5/YciO/YrdC/YwlC family protein -
LSO74_RS01890 (KRLU3655_LOCUS365) 373238..374044 + 807 WP_005658633.1 shikimate dehydrogenase -
LSO74_RS01895 (KRLU3655_LOCUS366) 374056..374808 + 753 WP_005658635.1 DUF3800 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(10-63)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-89)


Sequences

Toxin        


Download         Length: 74 a.a.        Molecular weight: 8834.35 Da        Isoelectric Point: 10.7588

>T294970 WP_005658624.1 NZ_OV040719:369528-369749 [Haemophilus influenzae]
VQNLLENQALFAILDGEIWELRPIRDRILFARLMDGRFVLLHQFMKKTQKTPKREIQTTQQRLSELKERLKNE

Download         Length: 222 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11092.94 Da        Isoelectric Point: 10.3139

>AT294970 WP_005650837.1 NZ_OV040719:369742-370038 [Haemophilus influenzae]
MNKISPLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVKNA

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3PB74

Antitoxin

Source ID Structure

References