Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 74878..75412 Replicon chromosome
Accession NZ_OV040719
Organism Haemophilus influenzae strain 3655 isolate 3655

Toxin (Protein)


Gene name relE Uniprot ID A0A0H3PGA1
Locus tag LSO74_RS00370 Protein ID WP_005655869.1
Coordinates 75122..75412 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0H3PEU6
Locus tag LSO74_RS00365 Protein ID WP_005655871.1
Coordinates 74878..75132 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LSO74_RS00330 (KRLU3655_LOCUS66) 69945..70310 + 366 WP_005655888.1 endonuclease domain-containing protein -
LSO74_RS00335 (KRLU3655_LOCUS67) 70450..70866 + 417 WP_005655886.1 hypothetical protein -
LSO74_RS00340 (KRLU3655_LOCUS68) 70912..72978 + 2067 WP_005655883.1 glycine--tRNA ligase subunit beta -
LSO74_RS00350 (KRLU3655_LOCUS69) 73339..74010 + 672 WP_005655881.1 integrase arm-type DNA-binding domain-containing protein -
LSO74_RS00355 (KRLU3655_LOCUS70) 74040..74348 + 309 WP_005655879.1 P2 family phage major capsid protein -
LSO74_RS00360 (KRLU3655_LOCUS72) 74581..74787 + 207 WP_005655873.1 hypothetical protein -
LSO74_RS00365 (KRLU3655_LOCUS73) 74878..75132 + 255 WP_005655871.1 stability protein StbD Antitoxin
LSO74_RS00370 (KRLU3655_LOCUS74) 75122..75412 + 291 WP_005655869.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LSO74_RS00375 (KRLU3655_LOCUS75) 75629..75853 + 225 WP_005655867.1 hypothetical protein -
LSO74_RS00380 (KRLU3655_LOCUS76) 76322..77356 - 1035 WP_005655864.1 DNA polymerase III subunit delta -
LSO74_RS00385 (KRLU3655_LOCUS77) 77356..77859 - 504 WP_005651506.1 LPS assembly lipoprotein LptE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11510.47 Da        Isoelectric Point: 10.6484

>T294969 WP_005655869.1 NZ_OV040719:75122-75412 [Haemophilus influenzae]
MTYKLIFDKRALKEWNKLGETLRQQFKNKLVERMINPRIQADKLKGENDLYKIKLRSAGYRLVYQVRDQEITIIVVSVGK
RERLEVYKTAEQRTAH

Download         Length: 291 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9415.78 Da        Isoelectric Point: 4.0737

>AT294969 WP_005655871.1 NZ_OV040719:74878-75132 [Haemophilus influenzae]
MALHQILAEQAASITDLKRNPMGVIQESESGIVAILNRNQPAFYCITPELFSHMQELIEDLELGRIANERLATLEPIEVD
LNDL

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3PGA1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3PEU6

References