Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1568462..1569051 Replicon chromosome
Accession NZ_OV040584
Organism Haemophilus influenzae isolate KR271

Toxin (Protein)


Gene name hicA Uniprot ID Q4QL51
Locus tag LSO75_RS07770 Protein ID WP_005653200.1
Coordinates 1568803..1569051 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q4QL50
Locus tag LSO75_RS07765 Protein ID WP_005653201.1
Coordinates 1568462..1568806 (-) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LSO75_RS07750 (KRLU271_LOCUS1455) 1563685..1565079 - 1395 WP_005657016.1 sodium-coupled multidrug efflux MATE transporter HmrM -
LSO75_RS07755 (KRLU271_LOCUS1456) 1565123..1565737 + 615 WP_005657019.1 riboflavin synthase -
LSO75_RS07760 (KRLU271_LOCUS1457) 1565809..1568418 - 2610 WP_044364349.1 aminopeptidase N -
LSO75_RS07765 (KRLU271_LOCUS1458) 1568462..1568806 - 345 WP_005653201.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LSO75_RS07770 (KRLU271_LOCUS1459) 1568803..1569051 - 249 WP_005653200.1 type II toxin-antitoxin system HicA family toxin Toxin
LSO75_RS07775 (KRLU271_LOCUS1460) 1569222..1569716 + 495 WP_005653194.1 5-(carboxyamino)imidazole ribonucleotide mutase -
LSO75_RS07780 (KRLU271_LOCUS1461) 1569786..1570874 + 1089 WP_005686592.1 5-(carboxyamino)imidazole ribonucleotide synthase -
LSO75_RS07785 (KRLU271_LOCUS1462) 1571014..1572204 + 1191 WP_005657030.1 amino acid aminotransferase -
LSO75_RS07790 (KRLU271_LOCUS1463) 1572311..1572937 - 627 WP_011272462.1 energy-coupling factor ABC transporter ATP-binding protein -
LSO75_RS07795 (KRLU271_LOCUS1464) 1572939..1573571 - 633 WP_011272461.1 energy-coupling factor transporter transmembrane protein EcfT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-102)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9425.93 Da        Isoelectric Point: 10.4673

>T294968 WP_005653200.1 NZ_OV040584:c1569051-1568803 [Haemophilus influenzae]
MGRTEKLLDKLAQSKSTFNWNELVSLLAQQGYEKREMAGSRVRFYNRTLEHTILLHKPHPENYIKGGALKSVKESLKQVG
IL

Download         Length: 249 bp

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13142.04 Da        Isoelectric Point: 4.8151

>AT294968 WP_005653201.1 NZ_OV040584:c1568806-1568462 [Haemophilus influenzae]
MKLLNYKGYVGTIEADLENNILFGKLAYIRDLVTYEAESLSELEKEFRQSVDLYLQDCLELGKEPNKPFKGVFNVRIGEE
LHREATIIAGDRSLNAFVTEAIQEKIFREKPSLR

Download         Length: 345 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5M6BP03

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GMF9

References