Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1211686..1212220 Replicon chromosome
Accession NZ_OV040584
Organism Haemophilus influenzae isolate KR271

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LSO75_RS05965 Protein ID WP_044364318.1
Coordinates 1212041..1212220 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID E7A432
Locus tag LSO75_RS05960 Protein ID WP_013525736.1
Coordinates 1211686..1211961 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LSO75_RS05940 (KRLU271_LOCUS1107) 1207089..1209128 - 2040 WP_038441065.1 excinuclease ABC subunit UvrB -
LSO75_RS05950 (KRLU271_LOCUS1108) 1209744..1210712 - 969 WP_038441067.1 zinc transporter permease subunit ZevB -
LSO75_RS05955 (KRLU271_LOCUS1109) 1210715..1211335 - 621 WP_044364321.1 zinc transporter binding subunit ZevA -
LSO75_RS05960 (KRLU271_LOCUS1110) 1211686..1211961 + 276 WP_013525736.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LSO75_RS05965 (KRLU271_LOCUS1111) 1212041..1212220 + 180 WP_044364318.1 type II toxin-antitoxin system YafQ family toxin Toxin
LSO75_RS05970 (KRLU271_LOCUS1112) 1212315..1213985 + 1671 WP_044364316.1 energy-dependent translational throttle protein EttA -
LSO75_RS05975 (KRLU271_LOCUS1113) 1214047..1214388 + 342 WP_044364314.1 SirB2 family protein -
LSO75_RS05980 (KRLU271_LOCUS1114) 1214393..1216363 + 1971 WP_044364312.1 GNAT family N-acetyltransferase -
LSO75_RS05985 (KRLU271_LOCUS1115) 1216360..1216533 + 174 WP_005657572.1 DUF5363 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-58)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-81)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6883.07 Da        Isoelectric Point: 8.5134

>T294967 WP_044364318.1 NZ_OV040584:1212041-1212220 [Haemophilus influenzae]
MYCLLNSLPLPVKYKDHALTGNWKGWRDCHIKNDLVLIYKIVGDEIRLARLNTHSEIFG

Download         Length: 180 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10259.81 Da        Isoelectric Point: 6.0646

>AT294967 WP_013525736.1 NZ_OV040584:1211686-1211961 [Haemophilus influenzae]
MAAVSFRVPDETKNIAFEVIKSYGLSPTQALNMFLAQIAKTKAIPVSLDYQTEQMPNSKTIMAMAELDNHHGHEYKTLEE
FHQAMLAEMKS

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5C2R2R7

References