294965

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 569676..570154 Replicon chromosome
Accession NZ_OV040584
Organism Haemophilus influenzae isolate KR271

Toxin (Protein)


Gene name VapD Uniprot ID -
Locus tag LSO75_RS02880 Protein ID WP_044364768.1
Coordinates 569876..570154 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID Q4QN94
Locus tag LSO75_RS02875 Protein ID WP_011272059.1
Coordinates 569676..569867 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LSO75_RS02850 (KRLU271_LOCUS531) 565255..565887 + 633 WP_044365145.1 dTMP kinase -
LSO75_RS02855 (KRLU271_LOCUS532) 565884..566867 + 984 WP_044364765.1 DNA polymerase III subunit delta' -
LSO75_RS02860 (KRLU271_LOCUS533) 566922..567704 + 783 WP_011272061.1 YchF/TatD family DNA exonuclease -
LSO75_RS02865 (KRLU271_LOCUS534) 567731..568255 + 525 WP_011272060.1 DUF1523 family protein -
LSO75_RS02870 (KRLU271_LOCUS535) 568306..569604 + 1299 WP_005691371.1 hemolysin family protein -
LSO75_RS02875 (KRLU271_LOCUS536) 569676..569867 + 192 WP_011272059.1 DUF5397 family protein Antitoxin
LSO75_RS02880 (KRLU271_LOCUS537) 569876..570154 + 279 WP_044364768.1 virulence-associated protein VapD Toxin
LSO75_RS02885 (KRLU271_LOCUS538) 570247..570777 + 531 WP_050846092.1 hypothetical protein -
LSO75_RS02890 (KRLU271_LOCUS539) 570849..572348 + 1500 WP_011272056.1 fused PTS fructose transporter subunit IIA/HPr protein -
LSO75_RS02895 (KRLU271_LOCUS540) 572350..573291 + 942 WP_011272055.1 1-phosphofructokinase -
LSO75_RS02900 (KRLU271_LOCUS541) 573293..574963 + 1671 WP_011272054.1 fructose-specific PTS transporter subunit EIIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(1-63)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10598.99 Da        Isoelectric Point: 4.6712

>T294965 WP_044364768.1 NZ_OV040584:569876-570154 [Haemophilus influenzae]
MYAIAFDLVVKDTQDDHPKGVQEAYTDIGAVLAKFGFVRTQGSLYTNMNEDMANLFQAMNALKQLAWISQSVRDIRAFRI
EQWSDFTDFIRN

Download         Length: 279 bp

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7073.06 Da        Isoelectric Point: 3.8431

>AT294965 WP_011272059.1 NZ_OV040584:569676-569867 [Haemophilus influenzae]
MELRQQIPTGCIKQFGQFGVPYVVGEVAEFLPDGDVLVNITLLQSGEKDIYRLSYLLEDPEAE

Download         Length: 192 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6ZN8
AlphaFold DB Q4QN94

References