Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 46070..46701 Replicon chromosome
Accession NZ_OV040584
Organism Haemophilus influenzae isolate KR271

Toxin (Protein)


Gene name vapC Uniprot ID Q4QLW0
Locus tag LSO75_RS00220 Protein ID WP_005651560.1
Coordinates 46303..46701 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q4QLV9
Locus tag LSO75_RS00215 Protein ID WP_005648011.1
Coordinates 46070..46303 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LSO75_RS00190 (KRLU271_LOCUS39) 41550..42752 - 1203 WP_011272308.1 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC -
LSO75_RS00195 (KRLU271_LOCUS40) 42915..43580 + 666 WP_013526173.1 DNA repair protein RadC -
LSO75_RS00200 (KRLU271_LOCUS41) 43794..44030 + 237 WP_005542826.1 50S ribosomal protein L28 -
LSO75_RS00205 (KRLU271_LOCUS42) 44042..44212 + 171 WP_005613503.1 50S ribosomal protein L33 -
LSO75_RS00210 (KRLU271_LOCUS43) 44559..45923 + 1365 WP_044364467.1 diaminobutyrate--2-oxoglutarate transaminase -
LSO75_RS00215 (KRLU271_LOCUS44) 46070..46303 + 234 WP_005648011.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
LSO75_RS00220 (KRLU271_LOCUS45) 46303..46701 + 399 WP_005651560.1 tRNA(fMet)-specific endonuclease VapC Toxin
LSO75_RS00225 (KRLU271_LOCUS46) 46721..48256 + 1536 WP_044364470.1 L-2,4-diaminobutyrate decarboxylase -
LSO75_RS00230 (KRLU271_LOCUS47) 48487..49302 + 816 WP_044364472.1 DNA-formamidopyrimidine glycosylase -
LSO75_RS00235 (KRLU271_LOCUS48) 49376..50398 - 1023 WP_005651554.1 outer membrane-stress sensor serine endopeptidase DegS -
LSO75_RS00240 (KRLU271_LOCUS49) 50399..51517 - 1119 WP_005686201.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(7-56)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15115.46 Da        Isoelectric Point: 8.0514

>T294962 WP_005651560.1 NZ_OV040584:46303-46701 [Haemophilus influenzae]
VLKYMLDTNIVIYVIKRRPLEILSRFNQNAGKMCVSSITVAELYYGAEKSEYPERNIAVIEDFLSRLTILDYQPKHAAHF
GNIKAELSKQGKLIGENDIHIAAHARSEGLILVSNNLREFERVIALRTENWV

Download         Length: 399 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8880.98 Da        Isoelectric Point: 4.4013

>AT294962 WP_005648011.1 NZ_OV040584:46070-46303 [Haemophilus influenzae]
MIEASVFMTNRSQAVRLPAEVRFSEEIKKLSVRVSGSDRILSPLNQSWDSFFLNDQAVSDDFMNEREIAFQPEREAL

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q4QLW0

Antitoxin

Source ID Structure
AlphaFold DB A0A806DGS0

References