Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 1169864..1170494 Replicon chromosome
Accession NZ_OV024757
Organism Deinococcus radiodurans isolate DRR11

Toxin (Protein)


Gene name mazF Uniprot ID Q9RX98
Locus tag M7777_RS06055 Protein ID WP_010887062.1
Coordinates 1169864..1170217 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag M7777_RS06060 Protein ID WP_162177573.1
Coordinates 1170270..1170494 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M7777_RS06020 1165052..1165423 + 372 WP_227085985.1 inorganic pyrophosphatase -
M7777_RS06025 1165420..1166103 + 684 WP_010887056.1 SDR family oxidoreductase -
M7777_RS06030 1166124..1167086 + 963 WP_034349507.1 NAD(P)/FAD-dependent oxidoreductase -
M7777_RS06035 1167109..1167288 + 180 WP_034349506.1 hypothetical protein -
M7777_RS06040 1167290..1167919 + 630 WP_027479568.1 HAD family hydrolase -
M7777_RS06045 1167967..1169487 - 1521 WP_010887060.1 carboxylesterase/lipase family protein -
M7777_RS06050 1169628..1169870 + 243 WP_010887061.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
M7777_RS06055 1169864..1170217 + 354 WP_010887062.1 endoribonuclease MazF Toxin
M7777_RS06060 1170270..1170494 + 225 WP_162177573.1 hypothetical protein Antitoxin
M7777_RS06065 1170491..1170904 + 414 WP_010887064.1 type II toxin-antitoxin system VapC family toxin -
M7777_RS06070 1170901..1173368 + 2468 Protein_1176 ATP-dependent helicase HrpB -
M7777_RS06075 1173564..1174796 + 1233 WP_063653036.1 transposase -
M7777_RS06080 1174878..1175102 - 225 WP_162177572.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1173564..1174796 1232


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 12450.24 Da        Isoelectric Point: 7.3219

>T294960 WP_010887062.1 NZ_OV024757:1169864-1170217 [Deinococcus radiodurans]
MVSDYVPDAGHLVWLNFTPQAGHEQGGRRPALVLSPAAYNGVTGLMQACPVTSRAKGYPFEVTLPAHLGVSGVVLADHCR
SLDWRSRRAEQLAEAPADVLAEVRGKLGSLLGMSEKA

Download         Length: 354 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8229.23 Da        Isoelectric Point: 4.3481

>AT294960 WP_162177573.1 NZ_OV024757:1170270-1170494 [Deinococcus radiodurans]
MTTLEARIENGKVVLTPEQAAELGLREGEVLPVTIAPHEAETEGNPFTRWIGTLPPLPDGEESARFYRRLRDGE

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7D2M
PDB 7D2P
PDB 7DHP
PDB 7D2Q
PDB 7D28
PDB 7D2N

Antitoxin

Source ID Structure

References