Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 1169628..1170217 Replicon chromosome
Accession NZ_OV024757
Organism Deinococcus radiodurans isolate DRR11

Toxin (Protein)


Gene name mazF Uniprot ID Q9RX98
Locus tag M7777_RS06055 Protein ID WP_010887062.1
Coordinates 1169864..1170217 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q9RX99
Locus tag M7777_RS06050 Protein ID WP_010887061.1
Coordinates 1169628..1169870 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M7777_RS06015 1164640..1165059 + 420 WP_010887054.1 DinB family protein -
M7777_RS06020 1165052..1165423 + 372 WP_227085985.1 inorganic pyrophosphatase -
M7777_RS06025 1165420..1166103 + 684 WP_010887056.1 SDR family oxidoreductase -
M7777_RS06030 1166124..1167086 + 963 WP_034349507.1 NAD(P)/FAD-dependent oxidoreductase -
M7777_RS06035 1167109..1167288 + 180 WP_034349506.1 hypothetical protein -
M7777_RS06040 1167290..1167919 + 630 WP_027479568.1 HAD family hydrolase -
M7777_RS06045 1167967..1169487 - 1521 WP_010887060.1 carboxylesterase/lipase family protein -
M7777_RS06050 1169628..1169870 + 243 WP_010887061.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
M7777_RS06055 1169864..1170217 + 354 WP_010887062.1 endoribonuclease MazF Toxin
M7777_RS06060 1170270..1170494 + 225 WP_162177573.1 hypothetical protein -
M7777_RS06065 1170491..1170904 + 414 WP_010887064.1 type II toxin-antitoxin system VapC family toxin -
M7777_RS06070 1170901..1173368 + 2468 Protein_1176 ATP-dependent helicase HrpB -
M7777_RS06075 1173564..1174796 + 1233 WP_063653036.1 transposase -
M7777_RS06080 1174878..1175102 - 225 WP_162177572.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1173564..1174796 1232


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-112)

Antitoxin

Antitoxin PemI-like

(1-80)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 12450.24 Da        Isoelectric Point: 7.3219

>T294959 WP_010887062.1 NZ_OV024757:1169864-1170217 [Deinococcus radiodurans]
MVSDYVPDAGHLVWLNFTPQAGHEQGGRRPALVLSPAAYNGVTGLMQACPVTSRAKGYPFEVTLPAHLGVSGVVLADHCR
SLDWRSRRAEQLAEAPADVLAEVRGKLGSLLGMSEKA

Download         Length: 354 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8911.12 Da        Isoelectric Point: 4.3178

>AT294959 WP_010887061.1 NZ_OV024757:1169628-1169870 [Deinococcus radiodurans]
MTSQIQKWGNSLALRIPKALAQQVGLTQSSEVELLLQDGQIVIRPVPARQYDLAALLAEMTPENLHGETDWGALEGREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7D2M
PDB 7D2P
PDB 7DHP
PDB 7D2Q
PDB 7D28
PDB 7D2N

Antitoxin

Source ID Structure
PDB 7D2P
PDB 7D2Q
PDB 7D2N
AlphaFold DB Q9RX99

References