Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2484582..2486170 Replicon chromosome
Accession NZ_OU963893
Organism Unidentified bacterial endosymbiont isolate Enterobacter_chilo

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NL510_RS11820 Protein ID WP_253376834.1
Coordinates 2484582..2485901 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NL510_RS11825 Protein ID WP_253376836.1
Coordinates 2485901..2486170 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL510_RS11780 2479939..2480142 + 204 WP_253376826.1 hypothetical protein -
NL510_RS11785 2480922..2481815 + 894 WP_253384884.1 N-acetylmuramoyl-L-alanine amidase -
NL510_RS11790 2482072..2482365 - 294 Protein_2299 alpha/beta hydrolase -
NL510_RS11795 2482438..2482611 - 174 Protein_2300 flavodoxin -
NL510_RS11800 2482550..2482753 + 204 WP_253376828.1 DUF2514 family protein -
NL510_RS11805 2482919..2483239 + 321 WP_048029338.1 hypothetical protein -
NL510_RS11810 2483229..2483663 + 435 WP_253376830.1 DUF29 domain-containing protein -
NL510_RS11815 2484174..2484581 + 408 WP_253376832.1 hypothetical protein -
NL510_RS11820 2484582..2485901 - 1320 WP_253376834.1 type II toxin-antitoxin system HipA family toxin Toxin
NL510_RS11825 2485901..2486170 - 270 WP_253376836.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NL510_RS11830 2486326..2487618 - 1293 WP_253376838.1 glycosyl hydrolase family 28 protein -
NL510_RS11835 2487951..2488274 - 324 Protein_2308 MFS transporter -
NL510_RS11840 2488309..2489223 - 915 WP_253376840.1 bestrophin family protein -
NL510_RS11845 2489363..2490733 - 1371 WP_253376843.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-68)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49047.60 Da        Isoelectric Point: 7.2373

>T294953 WP_253376834.1 NZ_OU963893:c2485901-2484582 [unidentified bacterial endosymbiont]
MAKLVTWMNNERVGELIKQPNGAHTFHYAREWMDSRHARPLSLSLPLQFGQITSDAVFNFFDNLLPDSPVVRDRIVKRYH
ARSKQPFDLLAEIGRDSVGAVTLLAENEEISLPGMAWETLSEKKLEAVLSAYKSDIPLGMINEESDFRISVAGAQEKTAL
LKMSDAWCIPKATTPTTHIIKLPIGEIKQPNATLDLCDSVDNEYFCLLMAKTLGFDVPDAEIIIAGGVRALAVERFDRRW
SADRSVLFRLPQEDMCQAFGLPSSLKYESDGGPGIAEVMAFLLGSSEALADRYNFMRFLVFQWLLGATDGHAKNFSVFIL
PGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMSLNASKGRKNAIDKIHPRHFLATAKAVKFPQDQVWQILQDFVENVP
QALETVKMALPERFSQKVARSITENVLRLHARLVKNLAR

Download         Length: 1320 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10244.73 Da        Isoelectric Point: 9.7693

>AT294953 WP_253376836.1 NZ_OU963893:c2486170-2485901 [unidentified bacterial endosymbiont]
MKPPMIFSPIQLANYMKLMRQKNNWTQSALAKKIGIKQATVSNFENNPDKTTLTTFFKILQSLEMTLALHERGDARAQSS
DDNQQDLDW

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References