Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1(toxin) |
Location | 4649413..4650029 | Replicon | chromosome |
Accession | NZ_OU943338 | ||
Organism | Salmonella enterica subsp. enterica serovar Typhi strain MDUST348 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | Q8Z2U3 |
Locus tag | AFF66_RS23030 | Protein ID | WP_000238494.1 |
Coordinates | 4649413..4649787 (-) | Length | 125 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | A0A8E9YHE9 |
Locus tag | AFF66_RS23035 | Protein ID | WP_001523745.1 |
Coordinates | 4649787..4650029 (-) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
AFF66_RS23015 (SAMEA2158835_04595) | 4646915..4647817 | + | 903 | WP_000331359.1 | formate dehydrogenase subunit beta | - |
AFF66_RS23020 (SAMEA2158835_04596) | 4647814..4648449 | + | 636 | WP_000829025.1 | formate dehydrogenase cytochrome b556 subunit | - |
AFF66_RS23025 (SAMEA2158835_04597) | 4648446..4649375 | + | 930 | WP_000027727.1 | formate dehydrogenase accessory protein FdhE | - |
AFF66_RS23030 (SAMEA2158835_04598) | 4649413..4649787 | - | 375 | WP_000238494.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
AFF66_RS23035 (SAMEA2158835_04599) | 4649787..4650029 | - | 243 | WP_001523745.1 | CopG family transcriptional regulator | Antitoxin |
AFF66_RS23040 (SAMEA2158835_04600) | 4650234..4651163 | + | 930 | WP_001162859.1 | alpha/beta hydrolase | - |
AFF66_RS23045 (SAMEA2158835_04601) | 4651249..4651560 | + | 312 | WP_000558160.1 | type II toxin-antitoxin system HigB family toxin | - |
AFF66_RS23050 (SAMEA2158835_04602) | 4651557..4652003 | + | 447 | WP_001259009.1 | type II toxin-antitoxin system HigA family antitoxin | - |
AFF66_RS23055 (SAMEA2158835_04603) | 4652018..4652959 | - | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
AFF66_RS23060 (SAMEA2158835_04604) | 4653004..4653441 | - | 438 | WP_000560975.1 | D-aminoacyl-tRNA deacylase | - |
AFF66_RS23065 (SAMEA2158835_04605) | 4653438..4654310 | - | 873 | WP_000921423.1 | virulence factor BrkB family protein | - |
AFF66_RS23070 (SAMEA2158835_04606) | 4654304..4654903 | - | 600 | WP_000965695.1 | glucose-1-phosphatase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 13908.18 Da Isoelectric Point: 7.3567
>T294948 WP_000238494.1 NZ_OU943338:c4649787-4649413 [Salmonella enterica subsp. enterica serovar Typhi]
MVKGSALFDTNILIDLFSGRIEAKHALEAYPPQNAISLITWMEVMVGAKKYHQENRTRIALSAFNIIGVTQEIAERSVIV
RQEYGMKLPDAIILATAQVHRCELVTRNTKDFADIPGVITPYHL
MVKGSALFDTNILIDLFSGRIEAKHALEAYPPQNAISLITWMEVMVGAKKYHQENRTRIALSAFNIIGVTQEIAERSVIV
RQEYGMKLPDAIILATAQVHRCELVTRNTKDFADIPGVITPYHL
Download Length: 375 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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