Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4649413..4650029 Replicon chromosome
Accession NZ_OU943338
Organism Salmonella enterica subsp. enterica serovar Typhi strain MDUST348

Toxin (Protein)


Gene name vapC Uniprot ID Q8Z2U3
Locus tag AFF66_RS23030 Protein ID WP_000238494.1
Coordinates 4649413..4649787 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8E9YHE9
Locus tag AFF66_RS23035 Protein ID WP_001523745.1
Coordinates 4649787..4650029 (-) Length 81 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AFF66_RS23015 (SAMEA2158835_04595) 4646915..4647817 + 903 WP_000331359.1 formate dehydrogenase subunit beta -
AFF66_RS23020 (SAMEA2158835_04596) 4647814..4648449 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
AFF66_RS23025 (SAMEA2158835_04597) 4648446..4649375 + 930 WP_000027727.1 formate dehydrogenase accessory protein FdhE -
AFF66_RS23030 (SAMEA2158835_04598) 4649413..4649787 - 375 WP_000238494.1 type II toxin-antitoxin system VapC family toxin Toxin
AFF66_RS23035 (SAMEA2158835_04599) 4649787..4650029 - 243 WP_001523745.1 CopG family transcriptional regulator Antitoxin
AFF66_RS23040 (SAMEA2158835_04600) 4650234..4651163 + 930 WP_001162859.1 alpha/beta hydrolase -
AFF66_RS23045 (SAMEA2158835_04601) 4651249..4651560 + 312 WP_000558160.1 type II toxin-antitoxin system HigB family toxin -
AFF66_RS23050 (SAMEA2158835_04602) 4651557..4652003 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin -
AFF66_RS23055 (SAMEA2158835_04603) 4652018..4652959 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
AFF66_RS23060 (SAMEA2158835_04604) 4653004..4653441 - 438 WP_000560975.1 D-aminoacyl-tRNA deacylase -
AFF66_RS23065 (SAMEA2158835_04605) 4653438..4654310 - 873 WP_000921423.1 virulence factor BrkB family protein -
AFF66_RS23070 (SAMEA2158835_04606) 4654304..4654903 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(7-115)

Antitoxin

(13-47)


Sequences


Toxin        


Download         Length: 125 a.a.        Molecular weight: 13908.18 Da        Isoelectric Point: 7.3567

>T294948 WP_000238494.1 NZ_OU943338:c4649787-4649413 [Salmonella enterica subsp. enterica serovar Typhi]
MVKGSALFDTNILIDLFSGRIEAKHALEAYPPQNAISLITWMEVMVGAKKYHQENRTRIALSAFNIIGVTQEIAERSVIV
RQEYGMKLPDAIILATAQVHRCELVTRNTKDFADIPGVITPYHL

Download         Length: 375 bp


Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9437.77 Da        Isoelectric Point: 4.4463

>AT294948 WP_001523745.1 NZ_OU943338:c4650029-4649787 [Salmonella enterica subsp. enterica serovar Typhi]
MMAGMDMGRILLDLSDDVIKRLDDLKVQRNLPRAELLREAVEQYLERQDRAETTISKALGLWQGCEEDGVEYQRKLREEW

Download         Length: 243 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A5I6CND8


Antitoxin

Source ID Structure

References