Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 4264331..4265112 | Replicon | chromosome |
| Accession | NZ_OU943338 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhi strain MDUST348 | ||
Toxin (Protein)
| Gene name | TacT2 | Uniprot ID | Q8Z1M4 |
| Locus tag | AFF66_RS21205 | Protein ID | WP_000626103.1 |
| Coordinates | 4264331..4264822 (-) | Length | 164 a.a. |
Antitoxin (Protein)
| Gene name | TacA2 | Uniprot ID | Q8Z1M5 |
| Locus tag | AFF66_RS21210 | Protein ID | WP_001110456.1 |
| Coordinates | 4264819..4265112 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AFF66_RS21180 (SAMEA2158835_04234) | 4260098..4261462 | - | 1365 | WP_000018529.1 | SPI-7-type island replicative DNA helicase | - |
| AFF66_RS21185 (SAMEA2158835_04235) | 4261459..4262409 | - | 951 | WP_000068773.1 | ParA family protein | - |
| AFF66_RS21190 | 4262707..4262781 | - | 75 | Protein_4153 | helix-turn-helix domain-containing protein | - |
| AFF66_RS21195 | 4263161..4263238 | + | 78 | Protein_4154 | porin family protein | - |
| AFF66_RS21200 (SAMEA2158835_04236) | 4263338..4264090 | + | 753 | WP_001785756.1 | non-specific acid phosphatase | - |
| AFF66_RS21205 (SAMEA2158835_04237) | 4264331..4264822 | - | 492 | WP_000626103.1 | GNAT family N-acetyltransferase | Toxin |
| AFF66_RS21210 (SAMEA2158835_04238) | 4264819..4265112 | - | 294 | WP_001110456.1 | DUF1778 domain-containing protein | Antitoxin |
| AFF66_RS21215 | 4265429..4265651 | + | 223 | Protein_4158 | hypothetical protein | - |
| AFF66_RS21220 (SAMEA2158835_04239) | 4265917..4266792 | + | 876 | WP_000921674.1 | AraC family transcriptional regulator | - |
| AFF66_RS21225 (SAMEA2158835_04240) | 4266789..4267076 | + | 288 | WP_001269916.1 | transcriptional regulator RtsB | - |
| AFF66_RS21230 | 4267099..4267315 | + | 217 | Protein_4161 | hypothetical protein | - |
| AFF66_RS21235 (SAMEA2158835_04241) | 4267323..4267667 | + | 345 | WP_100680417.1 | Ig-like domain-containing protein | - |
| AFF66_RS21240 (SAMEA2158835_04242) | 4267954..4268859 | - | 906 | WP_001268195.1 | YjiK family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17675.47 Da Isoelectric Point: 7.2652
>T294947 WP_000626103.1 NZ_OU943338:c4264822-4264331 [Salmonella enterica subsp. enterica serovar Typhi]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQWVGFVPSPMDPMMLMVTLGDLV
ESV
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQWVGFVPSPMDPMMLMVTLGDLV
ESV
Download Length: 492 bp
Antitoxin
Download Length: 98 a.a. Molecular weight: 11005.67 Da Isoelectric Point: 8.6141
>AT294947 WP_001110456.1 NZ_OU943338:c4265112-4264819 [Salmonella enterica subsp. enterica serovar Typhi]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEVLIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEVLIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
Download Length: 294 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A718CB38 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A716NSU2 |