Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4024881..4025397 Replicon chromosome
Accession NZ_OU943338
Organism Salmonella enterica subsp. enterica serovar Typhi strain MDUST348

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag AFF66_RS19880 Protein ID WP_000220578.1
Coordinates 4024881..4025165 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag AFF66_RS19885 Protein ID WP_000212724.1
Coordinates 4025155..4025397 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AFF66_RS19865 (SAMEA2158835_03973) 4020093..4021745 + 1653 WP_000155051.1 alpha,alpha-phosphotrehalase -
AFF66_RS19870 (SAMEA2158835_03974) 4022154..4024292 + 2139 WP_000187820.1 anaerobic ribonucleoside-triphosphate reductase -
AFF66_RS19875 (SAMEA2158835_03975) 4024413..4024877 + 465 WP_001268860.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
AFF66_RS19880 (SAMEA2158835_03976) 4024881..4025165 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AFF66_RS19885 (SAMEA2158835_03977) 4025155..4025397 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
AFF66_RS19890 (SAMEA2158835_03978) 4025475..4027388 - 1914 WP_001212152.1 BglG family transcription antiterminator -
AFF66_RS19895 (SAMEA2158835_03979) 4027405..4028145 - 741 WP_000779260.1 KDGP aldolase family protein -
AFF66_RS19900 (SAMEA2158835_03980) 4028142..4029260 - 1119 WP_001139189.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
AFF66_RS19905 (SAMEA2158835_03981) 4029244..4030377 - 1134 WP_000459938.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T294945 WP_000220578.1 NZ_OU943338:c4025165-4024881 [Salmonella enterica subsp. enterica serovar Typhi]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT294945 WP_000212724.1 NZ_OU943338:c4025397-4025155 [Salmonella enterica subsp. enterica serovar Typhi]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References