Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1390029..1390649 Replicon chromosome
Accession NZ_OU943338
Organism Salmonella enterica subsp. enterica serovar Typhi strain MDUST348

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag AFF66_RS06780 Protein ID WP_001280991.1
Coordinates 1390029..1390247 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag AFF66_RS06785 Protein ID WP_000344807.1
Coordinates 1390275..1390649 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AFF66_RS06740 (SAMEA2158835_01366) 1385252..1385821 + 570 WP_000779802.1 YbaY family lipoprotein -
AFF66_RS06745 (SAMEA2158835_01367) 1385854..1386243 - 390 WP_000961285.1 MGMT family protein -
AFF66_RS06755 (SAMEA2158835_01368) 1386474..1388024 - 1551 WP_000213129.1 EAL domain-containing protein -
AFF66_RS06760 (SAMEA2158835_01369) 1388249..1388509 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
AFF66_RS06765 1388515..1388655 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
AFF66_RS06770 (SAMEA2158835_01370) 1388711..1389181 - 471 WP_000136183.1 YlaC family protein -
AFF66_RS06775 (SAMEA2158835_01371) 1389299..1389850 - 552 WP_001278793.1 maltose O-acetyltransferase -
AFF66_RS06780 (SAMEA2158835_01372) 1390029..1390247 - 219 WP_001280991.1 HHA domain-containing protein Toxin
AFF66_RS06785 (SAMEA2158835_01373) 1390275..1390649 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
AFF66_RS06790 (SAMEA2158835_01374) 1391145..1394294 - 3150 WP_001132507.1 efflux RND transporter permease AcrB -
AFF66_RS06795 (SAMEA2158835_01375) 1394317..1395510 - 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T294939 WP_001280991.1 NZ_OU943338:c1390247-1390029 [Salmonella enterica subsp. enterica serovar Typhi]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT294939 WP_000344807.1 NZ_OU943338:c1390649-1390275 [Salmonella enterica subsp. enterica serovar Typhi]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References