Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 204197..204957 Replicon chromosome
Accession NZ_OU943338
Organism Salmonella enterica subsp. enterica serovar Typhi strain MDUST348

Toxin (Protein)


Gene name tacT Uniprot ID Q8Z2B1
Locus tag AFF66_RS00960 Protein ID WP_000533908.1
Coordinates 204472..204957 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID Q8Z2B2
Locus tag AFF66_RS00955 Protein ID WP_000965889.1
Coordinates 204197..204484 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AFF66_RS00935 (SAMEA2158835_00193) 199602..200513 + 912 WP_001168555.1 glycine--tRNA ligase subunit alpha -
AFF66_RS00940 (SAMEA2158835_00194) 200523..202592 + 2070 WP_001291805.1 glycine--tRNA ligase subunit beta -
AFF66_RS00945 202982..203410 + 429 Protein_188 IS3 family transposase -
AFF66_RS00950 (SAMEA2158835_00195) 203552..204019 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
AFF66_RS00955 (SAMEA2158835_00196) 204197..204484 + 288 WP_000965889.1 DUF1778 domain-containing protein Antitoxin
AFF66_RS00960 (SAMEA2158835_00197) 204472..204957 + 486 WP_000533908.1 GNAT family N-acetyltransferase Toxin
AFF66_RS00965 (SAMEA2158835_00198) 205328..205867 - 540 WP_000047148.1 copper-binding periplasmic metallochaperone CueP -
AFF66_RS00970 (SAMEA2158835_00199) 206043..206255 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
AFF66_RS00975 (SAMEA2158835_00200) 206546..206833 - 288 Protein_194 HTH-type transcriptional regulator -
AFF66_RS00980 (SAMEA2158835_00201) 207272..207982 + 711 WP_000190524.1 DUF3053 domain-containing protein -
AFF66_RS00985 (SAMEA2158835_00202) 208032..209006 - 975 WP_000804690.1 glyoxylate/hydroxypyruvate reductase GhrB -
AFF66_RS00990 (SAMEA2158835_00203) 209225..209887 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(13-89)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17689.38 Da        Isoelectric Point: 9.8719

>T294935 WP_000533908.1 NZ_OU943338:204472-204957 [Salmonella enterica subsp. enterica serovar Typhi]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEDAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10964.59 Da        Isoelectric Point: 4.6811

>AT294935 WP_000965889.1 NZ_OU943338:204197-204484 [Salmonella enterica subsp. enterica serovar Typhi]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACRAAENVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A714MHS9

Antitoxin

Source ID Structure
AlphaFold DB A0A752RW74

References