Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 4264473..4265254 | Replicon | chromosome |
| Accession | NZ_OU943337 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhi strain MDUST255 | ||
Toxin (Protein)
| Gene name | TacT2 | Uniprot ID | Q8Z1M4 |
| Locus tag | AE465_RS21110 | Protein ID | WP_000626103.1 |
| Coordinates | 4264473..4264964 (-) | Length | 164 a.a. |
Antitoxin (Protein)
| Gene name | TacA2 | Uniprot ID | Q8Z1M5 |
| Locus tag | AE465_RS21115 | Protein ID | WP_001110456.1 |
| Coordinates | 4264961..4265254 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AE465_RS21085 (SAMEA2145578_04243) | 4260240..4261604 | - | 1365 | WP_000018529.1 | SPI-7-type island replicative DNA helicase | - |
| AE465_RS21090 (SAMEA2145578_04244) | 4261601..4262635 | - | 1035 | WP_001195363.1 | ParA family protein | - |
| AE465_RS21095 | 4262849..4262923 | - | 75 | Protein_4133 | helix-turn-helix domain-containing protein | - |
| AE465_RS21100 | 4263303..4263380 | + | 78 | Protein_4134 | porin family protein | - |
| AE465_RS21105 (SAMEA2145578_04245) | 4263480..4264232 | + | 753 | WP_001785756.1 | non-specific acid phosphatase | - |
| AE465_RS21110 (SAMEA2145578_04246) | 4264473..4264964 | - | 492 | WP_000626103.1 | GNAT family N-acetyltransferase | Toxin |
| AE465_RS21115 (SAMEA2145578_04247) | 4264961..4265254 | - | 294 | WP_001110456.1 | DUF1778 domain-containing protein | Antitoxin |
| AE465_RS21120 | 4265571..4265793 | + | 223 | Protein_4138 | hypothetical protein | - |
| AE465_RS21125 (SAMEA2145578_04248) | 4266059..4266934 | + | 876 | WP_000921674.1 | AraC family transcriptional regulator | - |
| AE465_RS21130 (SAMEA2145578_04249) | 4266931..4267218 | + | 288 | WP_001269916.1 | transcriptional regulator RtsB | - |
| AE465_RS21135 | 4267241..4267457 | + | 217 | Protein_4141 | hypothetical protein | - |
| AE465_RS21140 (SAMEA2145578_04250) | 4267465..4267809 | + | 345 | WP_100680417.1 | Ig-like domain-containing protein | - |
| AE465_RS21145 (SAMEA2145578_04251) | 4268096..4269001 | - | 906 | WP_001268195.1 | YjiK family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17675.47 Da Isoelectric Point: 7.2652
>T294932 WP_000626103.1 NZ_OU943337:c4264964-4264473 [Salmonella enterica subsp. enterica serovar Typhi]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQWVGFVPSPMDPMMLMVTLGDLV
ESV
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQWVGFVPSPMDPMMLMVTLGDLV
ESV
Download Length: 492 bp
Antitoxin
Download Length: 98 a.a. Molecular weight: 11005.67 Da Isoelectric Point: 8.6141
>AT294932 WP_001110456.1 NZ_OU943337:c4265254-4264961 [Salmonella enterica subsp. enterica serovar Typhi]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEVLIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEVLIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
Download Length: 294 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A718CB38 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A716NSU2 |