Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 3921792..3922368 Replicon chromosome
Accession NZ_OU943337
Organism Salmonella enterica subsp. enterica serovar Typhi strain MDUST255

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag AE465_RS19305 Protein ID WP_001131963.1
Coordinates 3922081..3922368 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag AE465_RS19300 Protein ID WP_000063142.1
Coordinates 3921792..3922094 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AE465_RS19285 (SAMEA2145578_03882) 3918302..3920452 + 2151 WP_000379928.1 pyruvate/proton symporter BtsT -
AE465_RS19290 (SAMEA2145578_03883) 3920547..3920750 + 204 WP_000460616.1 YbdD/YjiX family protein -
AE465_RS19295 (SAMEA2145578_03884) 3920761..3921717 + 957 WP_000187846.1 GTPase -
AE465_RS19300 (SAMEA2145578_03885) 3921792..3922094 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
AE465_RS19305 (SAMEA2145578_03886) 3922081..3922368 - 288 WP_001131963.1 BrnT family toxin Toxin
AE465_RS19310 (SAMEA2145578_03887) 3922621..3923535 - 915 WP_000290515.1 restriction endonuclease -
AE465_RS19315 (SAMEA2145578_03888) 3923733..3927242 + 3510 WP_001043493.1 type I restriction-modification system endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T294929 WP_001131963.1 NZ_OU943337:c3922368-3922081 [Salmonella enterica subsp. enterica serovar Typhi]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT294929 WP_000063142.1 NZ_OU943337:c3922094-3921792 [Salmonella enterica subsp. enterica serovar Typhi]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References