Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3341719..3342339 Replicon chromosome
Accession NZ_OU943337
Organism Salmonella enterica subsp. enterica serovar Typhi strain MDUST255

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag AE465_RS16590 Protein ID WP_001280991.1
Coordinates 3342121..3342339 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag AE465_RS16585 Protein ID WP_000344807.1
Coordinates 3341719..3342093 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AE465_RS16575 (SAMEA2145578_03334) 3336858..3338051 + 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
AE465_RS16580 (SAMEA2145578_03335) 3338074..3341223 + 3150 WP_001132507.1 efflux RND transporter permease AcrB -
AE465_RS16585 (SAMEA2145578_03336) 3341719..3342093 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
AE465_RS16590 (SAMEA2145578_03337) 3342121..3342339 + 219 WP_001280991.1 HHA domain-containing protein Toxin
AE465_RS16595 (SAMEA2145578_03338) 3342518..3343069 + 552 WP_001278793.1 maltose O-acetyltransferase -
AE465_RS16600 (SAMEA2145578_03339) 3343187..3343657 + 471 WP_000136183.1 YlaC family protein -
AE465_RS16605 3343713..3343853 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
AE465_RS16610 (SAMEA2145578_03340) 3343859..3344119 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
AE465_RS16615 (SAMEA2145578_03341) 3344344..3345894 + 1551 WP_000213129.1 EAL domain-containing protein -
AE465_RS16625 (SAMEA2145578_03342) 3346125..3346514 + 390 WP_000961285.1 MGMT family protein -
AE465_RS16630 (SAMEA2145578_03343) 3346547..3347116 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T294928 WP_001280991.1 NZ_OU943337:3342121-3342339 [Salmonella enterica subsp. enterica serovar Typhi]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT294928 WP_000344807.1 NZ_OU943337:3341719-3342093 [Salmonella enterica subsp. enterica serovar Typhi]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References