Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 805104..805752 Replicon chromosome
Accession NZ_OU943337
Organism Salmonella enterica subsp. enterica serovar Typhi strain MDUST255

Toxin (Protein)


Gene name cptA Uniprot ID A0A715BCB4
Locus tag AE465_RS03915 Protein ID WP_000244762.1
Coordinates 805351..805752 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag AE465_RS03910 Protein ID WP_000351186.1
Coordinates 805104..805370 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AE465_RS03890 (SAMEA2145578_00801) 801032..802465 - 1434 WP_001230148.1 6-phospho-beta-glucosidase BglA -
AE465_RS03895 (SAMEA2145578_00802) 802624..802935 + 312 WP_001182971.1 N(4)-acetylcytidine aminohydrolase -
AE465_RS03900 (SAMEA2145578_00803) 803099..803758 + 660 WP_000250289.1 hemolysin III family protein -
AE465_RS03905 (SAMEA2145578_00805) 803874..804854 - 981 WP_000874170.1 tRNA-modifying protein YgfZ -
AE465_RS03910 (SAMEA2145578_00806) 805104..805370 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
AE465_RS03915 (SAMEA2145578_00807) 805351..805752 + 402 WP_000244762.1 protein YgfX Toxin
AE465_RS03920 (SAMEA2145578_00808) 805817..806338 - 522 WP_001055885.1 flavodoxin FldB -
AE465_RS03925 (SAMEA2145578_00809) 806451..807347 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
AE465_RS03930 (SAMEA2145578_00810) 807371..808084 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AE465_RS03935 (SAMEA2145578_00811) 808090..809823 + 1734 WP_000813396.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15773.75 Da        Isoelectric Point: 10.7537

>T294921 WP_000244762.1 NZ_OU943337:805351-805752 [Salmonella enterica subsp. enterica serovar Typhi]
VVLWQSDLRVSWRAQWISLLLHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPI

Download         Length: 402 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT294921 WP_000351186.1 NZ_OU943337:805104-805370 [Salmonella enterica subsp. enterica serovar Typhi]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A715BCB4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References