29492

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3104952..3105522 Replicon chromosome
Accession NC_021251
Organism Mycobacterium tuberculosis CCDC5079

Toxin (Protein)


Gene name mazF Uniprot ID P71650
Locus tag CFBS_RS14800 Protein ID WP_003414166.1
Coordinates 3104952..3105308 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL61
Locus tag CFBS_RS14805 Protein ID WP_003901465.1
Coordinates 3105292..3105522 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFBS_RS14780 3100404..3102092 - 1689 WP_003414155.1 alpha/beta hydrolase family protein -
CFBS_RS14785 3102096..3102422 - 327 WP_003414157.1 hypothetical protein -
CFBS_RS14790 3102595..3103182 + 588 WP_003914429.1 DUF3558 family protein -
CFBS_RS14795 3103201..3104850 + 1650 WP_003899485.1 CocE/NonD family hydrolase -
CFBS_RS14800 3104952..3105308 - 357 WP_003414166.1 type II toxin-antitoxin system toxin endoribonuclease MazF9 Toxin
CFBS_RS14805 3105292..3105522 - 231 WP_003901465.1 antitoxin MazE Antitoxin
CFBS_RS14810 3105565..3106608 - 1044 WP_003414172.1 DUF2293 domain-containing protein -
CFBS_RS22330 3106799..3107074 + 276 WP_003911993.1 DUF1778 domain-containing protein -
CFBS_RS22550 3107250..3107504 - 255 WP_003917684.1 hypothetical protein -
CFBS_RS14825 3107652..3108056 + 405 WP_003414181.1 hypothetical protein -
CFBS_RS14830 3108053..3108244 + 192 WP_003414184.1 hypothetical protein -
CFBS_RS14835 3108308..3109597 + 1290 Protein_2893 transposase family protein -
CFBS_RS14840 3109831..3110088 + 258 WP_003899489.1 hypothetical protein -
CFBS_RS14845 3110193..3110504 + 312 WP_003414190.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-29)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12858.73 Da        Isoelectric Point: 9.1962

>T29492 WP_003414166.1 NC_021251:c3105308-3104952 [Mycobacterium tuberculosis CCDC5079]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS

Download         Length: 357 bp

>T29492 NC_021251:c3105308-3104952 [Mycobacterium tuberculosis CCDC5079]
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8231.01 Da        Isoelectric Point: 4.1809

>AT29492 WP_003901465.1 NC_021251:c3105522-3105292 [Mycobacterium tuberculosis CCDC5079]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR

Download         Length: 231 bp

>AT29492 NC_021251:c3105522-3105292 [Mycobacterium tuberculosis CCDC5079]
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L2A
PDB 5HJZ
PDB 6KYT
PDB 6L29
PDB 7DU5
PDB 6KYS

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FBW3

References