Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4264609..4265390 Replicon chromosome
Accession NZ_OU943336
Organism Salmonella enterica subsp. enterica serovar Typhi strain MDUST305

Toxin (Protein)


Gene name TacT2 Uniprot ID Q8Z1M4
Locus tag AEG13_RS21215 Protein ID WP_000626103.1
Coordinates 4264609..4265100 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID Q8Z1M5
Locus tag AEG13_RS21220 Protein ID WP_001110456.1
Coordinates 4265097..4265390 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AEG13_RS21190 (SAMEA1964467_04239) 4260376..4261740 - 1365 WP_000018529.1 SPI-7-type island replicative DNA helicase -
AEG13_RS21195 (SAMEA1964467_04240) 4261737..4262771 - 1035 WP_001195363.1 ParA family protein -
AEG13_RS21200 4262985..4263059 - 75 Protein_4154 helix-turn-helix domain-containing protein -
AEG13_RS21205 4263439..4263516 + 78 Protein_4155 porin family protein -
AEG13_RS21210 (SAMEA1964467_04241) 4263616..4264368 + 753 WP_001785756.1 non-specific acid phosphatase -
AEG13_RS21215 (SAMEA1964467_04242) 4264609..4265100 - 492 WP_000626103.1 GNAT family N-acetyltransferase Toxin
AEG13_RS21220 (SAMEA1964467_04243) 4265097..4265390 - 294 WP_001110456.1 DUF1778 domain-containing protein Antitoxin
AEG13_RS21225 4265707..4265929 + 223 Protein_4159 hypothetical protein -
AEG13_RS21230 (SAMEA1964467_04244) 4266195..4267070 + 876 WP_000921674.1 AraC family transcriptional regulator -
AEG13_RS21235 (SAMEA1964467_04245) 4267067..4267354 + 288 WP_001269916.1 transcriptional regulator RtsB -
AEG13_RS21240 4267377..4267593 + 217 Protein_4162 hypothetical protein -
AEG13_RS21245 (SAMEA1964467_04246) 4267601..4267945 + 345 WP_100680417.1 Ig-like domain-containing protein -
AEG13_RS21250 (SAMEA1964467_04247) 4268232..4269137 - 906 WP_001268195.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17675.47 Da        Isoelectric Point: 7.2652

>T294917 WP_000626103.1 NZ_OU943336:c4265100-4264609 [Salmonella enterica subsp. enterica serovar Typhi]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQWVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11005.67 Da        Isoelectric Point: 8.6141

>AT294917 WP_001110456.1 NZ_OU943336:c4265390-4265097 [Salmonella enterica subsp. enterica serovar Typhi]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEVLIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A718CB38

Antitoxin

Source ID Structure
AlphaFold DB A0A716NSU2

References