Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4025157..4025673 Replicon chromosome
Accession NZ_OU943336
Organism Salmonella enterica subsp. enterica serovar Typhi strain MDUST305

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag AEG13_RS19890 Protein ID WP_000220578.1
Coordinates 4025157..4025441 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag AEG13_RS19895 Protein ID WP_000212724.1
Coordinates 4025431..4025673 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AEG13_RS19875 (SAMEA1964467_03978) 4020369..4022021 + 1653 WP_000155051.1 alpha,alpha-phosphotrehalase -
AEG13_RS19880 (SAMEA1964467_03979) 4022430..4024568 + 2139 WP_000187820.1 anaerobic ribonucleoside-triphosphate reductase -
AEG13_RS19885 (SAMEA1964467_03980) 4024689..4025153 + 465 WP_001268860.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
AEG13_RS19890 (SAMEA1964467_03981) 4025157..4025441 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AEG13_RS19895 (SAMEA1964467_03982) 4025431..4025673 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
AEG13_RS19900 (SAMEA1964467_03983) 4025751..4027664 - 1914 WP_001212152.1 BglG family transcription antiterminator -
AEG13_RS19905 (SAMEA1964467_03984) 4027681..4028421 - 741 WP_000779260.1 KDGP aldolase family protein -
AEG13_RS19910 (SAMEA1964467_03985) 4028418..4029536 - 1119 WP_001139189.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
AEG13_RS19915 (SAMEA1964467_03986) 4029520..4030653 - 1134 WP_000459938.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T294915 WP_000220578.1 NZ_OU943336:c4025441-4025157 [Salmonella enterica subsp. enterica serovar Typhi]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT294915 WP_000212724.1 NZ_OU943336:c4025673-4025431 [Salmonella enterica subsp. enterica serovar Typhi]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References